The Mystifying Role of Mast Cells in the Pathogenesis of Periapical Pathologies - a Systematic Review.

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2025-04-12 DOI:10.1016/j.joen.2025.04.001

Mala Kamboj, Shashibala Malik, R Keerthika, Anjali Narwal, Anju Devi, Gopikrishnan Vijayakumar, Adarsh Kumar

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引用次数: 0

Abstract

Introduction: Oral periapical lesions present a significant global health burden, with their pathogenesis shrouded in complexity due to multifaceted mechanisms. Despite extensive research, the precise role of mast cells in their pathogenesis remains elusive. The present systematic review aimed to elucidate the mechanism of mast cells in the immunopathology of periapical lesions.

Methods: An extensive literature search conducted across databases (MEDLINE via PubMed, Scopus, Cochrane Library, and EMBASE and gray literature) of original research articles that examined the role of mast cells in periapical lesions were investigated and selected for review. The risk of bias for each study was meticulously assessed using the QUADAS-2, and Review Manager 5.4 (RevMan v5.4, The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) was utilized to generate the results.

Results: A total of 41 published articles were included for data synthesis. The findings revealed significant variations in mast cell number within the fibrous capsule of periapical granuloma and periapical cyst, with notably elevated counts in the latter. Periapical granuloma manifested a predominance of granulated mast cells in the subepithelial region. In contrast, the periapical cyst exhibited a preponderance of degranulated mast cells in the deeper areas of the capsule.

Conclusions: The current evidence substantiates that mast cells play a crucial role in the pathogenesis, progression, fibrosis, and chronicity of periapical lesions.

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肥大细胞在根尖周围病变发病机制中的神秘作用——系统综述。

口腔根尖周围病变是全球性的重大健康负担，其发病机制复杂，机制多样。尽管进行了广泛的研究，肥大细胞在其发病机制中的确切作用仍然难以捉摸。本文旨在阐明肥大细胞在根尖周围病变免疫病理中的作用机制。方法：通过数据库（MEDLINE通过PubMed， Scopus, Cochrane Library， EMBASE和灰色文献）进行广泛的文献检索，对研究肥大细胞在根尖周围病变中的作用的原始研究文章进行调查并选择进行回顾。使用QUADAS-2对每项研究的偏倚风险进行仔细评估，并使用Review Manager 5.4 （RevMan v5.4, Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark）生成结果。结果：共纳入41篇已发表文章进行数据综合。结果显示，根尖周围肉芽肿和根尖周围囊肿纤维囊内的肥大细胞数量有显著差异，后者的肥大细胞数量明显升高。根尖周围肉芽肿表现为在上皮下区域以颗粒状肥大细胞为主。相反，根尖周围囊肿在被囊的较深区域显示出脱颗粒肥大细胞的优势。结论：目前的证据证实肥大细胞在根尖周围病变的发病、进展、纤维化和慢性中起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.