The relationship of cardiometabolic index with bowel movement frequency: an NHANES-based cross-sectional analysis.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-04-24 DOI:10.1186/s12944-025-02567-w

Qianyi Ren, Yanan Wang, Xinhui Han, Qingyi Wang, Guoying Liang

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引用次数: 0

Abstract

Background: Prior studies have indicated a notable link between gut health and metabolic syndrome (MetS). The cardiometabolic index (CMI), an innovative indicator of metabolic health, effectively predicts MetS. Bowel movement frequency (BMF) closely reflects gastrointestinal function and is a key sign of gut health. Nonetheless, the relationship between CMI and BMF is still unclear. Our research explores the possible association between these two variables.

Methods: This study employed 2005 to 2010 National Health and Nutrition Examination Survey data. The CMI for each participant was determined by triglycerides, high-density lipoprotein cholesterol, and the waist-to-hip ratio. Multiple regression, smooth curve fitting, and threshold effect analyses were employed to investigate the association between CMI and BMF. The association's stability across populations was assessed through subgroup analyses and interaction tests.

Results: The study included 9,678 participants in total. After controlling for potential confounding variables, those in the uppermost CMI quartile had a 0.69 more increase in BMF than the bottom quartile (β = 0.69, 95% CI: 0.34, 1.03). The trend analyses showed that BMF increased steadily with the advancement of the CMI quartiles (P for trend < 0.0001). Associations between CMI and BMF were shown to be nonlinear through smooth curve fitting and threshold effect analyses. Specifically, when CMI ranged from 4.97 to 11.75, a negative connection was observed (β = -0.78, 95% CI: -1.33, -0.23), while positive associations were identified in other ranges. Subgroup analyses and interaction tests indicated significant CMI and BMF association variations when stratified by depression and age categories (P for interaction < 0.05).

Conclusions: This research indicates that CMI is generally associated with an increase in BMF. However, when CMI ranges from 4.97 to 11.75, it is associated with a BMF decrease. Notably, the association of CMI and BMF is more potent in young, middle-aged, and depressed people.

查看原文本刊更多论文

心脏代谢指数与排便频率的关系：基于nhanes的横断面分析。

背景：先前的研究表明肠道健康与代谢综合征（MetS）之间存在显著联系。心脏代谢指数（CMI）是一种创新的代谢健康指标，可有效预测MetS。肠蠕动频率（BMF）密切反映胃肠功能，是肠道健康的关键标志。尽管如此，CMI和BMF之间的关系仍不清楚。我们的研究探讨了这两个变量之间可能存在的联系。方法：本研究采用2005 ~ 2010年全国健康与营养调查资料。每个参与者的CMI由甘油三酯、高密度脂蛋白胆固醇和腰臀比决定。采用多元回归、光滑曲线拟合和阈值效应分析探讨CMI与BMF的关系。通过亚组分析和相互作用测试评估了该关联在人群中的稳定性。结果：研究共纳入9678名参与者。在控制了潜在的混杂变量后，最高CMI四分位数的BMF增加比最低四分位数多0.69 （β = 0.69, 95% CI: 0.34, 1.03）。趋势分析表明，随着CMI四分位数的增加，骨密度稳步增加（P为趋势）。结论：本研究表明，CMI通常与骨密度增加有关。然而，当CMI在4.97到11.75之间时，它与BMF下降有关。值得注意的是，CMI和BMF的关联在年轻人、中年人和抑郁症患者中更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.