Oral microbiota signature predicts the prognosis of colorectal carcinoma.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-05-05 DOI:10.1038/s41522-025-00702-0

Shi-Hao Zhou, Yan Du, Wen-Qiong Xue, Min-Jun He, Ting Zhou, Zhi-Yang Zhao, Lu Pei, Yi-Wei Chen, Jin-Ru Xie, Chang-Ling Huang, Yong-Qiao He, Tong-Min Wang, Ying Liao, Wei-Hua Jia

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引用次数: 0

Abstract

Emerging evidence links oral-derived gut microbes to colorectal cancer (CRC) development, but CRC prognosis-related microbial alterations in oral remain underexplored. In a retrospective study of 312 CRC patients, we examined the oral microbiota using 16S rRNA gene full-length amplicon sequencing to identify prognostic microbial biomarkers for CRC. Neisseria oralis and Campylobacter gracilis increased CRC progression risk (HR = 2.63 with P = 0.007, HR = 2.27 with P = 0.001, respectively), while Treponema medium showed protective effects (HR = 0.41, P = 0.0002). A microbial risk score (MRS) incorporating these species effectively predicted CRC progression risk (C-index = 0.68, 95% CI = 0.61-0.76). When compared to a model constructed solely from clinical factors, including tumor stage, lymphatic metastasis, and perineural invasion, the predictive accuracy significantly improved with the addition of the MRS, resulting in a C-index rising to 0.77 (P = 2.33 × 10^-5). Our findings suggest that oral microbiota biomarkers may contribute to personalized CRC monitoring strategies, their implementation in clinical surveillance necessitates confirmatory studies.

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口腔微生物群特征预测结直肠癌的预后。

新出现的证据表明，口腔来源的肠道微生物与结直肠癌（CRC）的发展有关，但与结直肠癌预后相关的口腔微生物改变仍未得到充分研究。在一项对312例结直肠癌患者的回顾性研究中，我们使用16S rRNA基因全长扩增子测序检测口腔微生物群，以确定结直肠癌的预后微生物生物标志物。口腔奈瑟菌和股薄弯曲杆菌增加CRC进展风险（HR = 2.63, P = 0.007, HR = 2.27, P = 0.001），密螺旋体培养基有保护作用（HR = 0.41, P = 0.0002）。纳入这些物种的微生物风险评分（MRS）可有效预测结直肠癌进展风险（C-index = 0.68, 95% CI = 0.61-0.76）。与仅由临床因素（包括肿瘤分期、淋巴转移和神经周围浸润）构建的模型相比，MRS的加入显著提高了预测准确性，导致c指数上升至0.77 （P = 2.33 × 10-5）。我们的研究结果表明，口腔微生物群生物标志物可能有助于个性化的CRC监测策略，它们在临床监测中的实施需要验证性研究。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.