Anatomically resolved oscillatory bursts reveal dynamic motifs of thalamocortical activity during naturalistic stimulus viewing.

Abstract

Natural vision requires circuit mechanisms which process complex spatiotemporal stimulus features in parallel. In the mammalian forebrain, one signature of circuit activation is fast oscillatory dynamics, reflected in the local field potential (LFP). Using data from the Allen Neuropixels Visual Coding project, we show that local visual features in naturalistic stimuli induce in mouse primary visual cortex (V1) retinotopically specific oscillations in various frequency bands and V1 layers. Specifically, layer 4 (L4) narrowband gamma was linked to luminance, low-gamma to optic flow, and L4/L5 epsilon oscillations to contrast. These feature-specific oscillations were associated with distinct translaminar spike-phase coupling patterns, which were conserved across a range of stimuli containing the relevant visual features, suggesting that they might constitute feature-specific circuit motifs. Our findings highlight visually induced fast oscillations as markers of dynamic circuit motifs, which may support differential and multiplexed coding of complex visual input and thalamocortical information propagation.