Kaiyin Sheng, Xueqiu Chen, Yimin Yang, Jie Xia, Kaiyue Song, Chaoqun Yao, Yi Yang, Aifang DU, Guangxu Ma
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引用次数: 0
Abstract
Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals, including humans (Montoya and Liesenfeld, 2004). It occurs worldwide and can persist for a lifetime in mammals. Humans get infected by eating undercooked meat of animals containing the tissue cysts of this parasite. In immune-competent individuals, T. gondii infection usually does not cause significant clinical symptoms, whereas in pregnant or immunocompromised individuals, T. gondii infection (toxoplasmosis) can cause more serious problems like abortion and even death (Dunn et al., 1999; Wang et al., 2017). A combination of pyrimethamine and sulfadiazine is usually used to treat toxoplasmosis, although it is generally inefficient and causes side effects (Alday and Doggett, 2017). Worse still, there is a lack of vaccines to prevent T. gondii infection in humans or animals.
刚地弓形虫是一种单细胞寄生虫，可以感染包括人类在内的几乎所有温血动物（Montoya and Liesenfeld, 2004）。它发生在世界各地，并可能在哺乳动物中持续一生。人类通过食用含有这种寄生虫组织囊肿的未煮熟的动物肉而感染。在免疫正常的个体中，弓形虫感染通常不会引起明显的临床症状，而在孕妇或免疫功能低下的个体中，弓形虫感染（弓形虫病）可引起更严重的问题，如流产甚至死亡(Dunn et al., 1999；Wang等人，2017)。乙胺嘧啶和磺胺嘧啶的组合通常用于治疗弓形虫病，尽管它通常效率低下且会引起副作用（Alday和Doggett， 2017）。更糟糕的是，目前缺乏预防人类或动物感染弓形虫的疫苗。
期刊介绍：
Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community.
JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.
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