{"title":"The magic bullet: a tribute to Fritz Eckstein.","authors":"Erik De Clercq","doi":"10.1080/15257770.2025.2500048","DOIUrl":null,"url":null,"abstract":"<p><p>The first encounter I ever had with Fritz Eckstein was in 1969 at Stanford University to discuss a polyribonucleotide in which the phosphate was replaced by thiophosphate groups, engendering increased interferon induction (i.e. antiviral activity). His research work then focused on the versatility of oligonucleotides as potential therapeutics. Spanning a period of several decades, various other leads of research were undertaken, i.e. 2'- and 3'-amino or -azido-substituted deoxyribonucleoside analogs, hammerhead ribozymes, small non-coding mRNAs (siRNAs, miRNAs) for monitoring gene therapy, and thiophosphate-substituted nucleotide analogs to be used in RNA and DNA sequencing. This exemplary scientific career generated not one but a multitude of magic bullets for biomedical research and application.</p>","PeriodicalId":19343,"journal":{"name":"Nucleosides, Nucleotides & Nucleic Acids","volume":" ","pages":"1-9"},"PeriodicalIF":1.1000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleosides, Nucleotides & Nucleic Acids","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/15257770.2025.2500048","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The first encounter I ever had with Fritz Eckstein was in 1969 at Stanford University to discuss a polyribonucleotide in which the phosphate was replaced by thiophosphate groups, engendering increased interferon induction (i.e. antiviral activity). His research work then focused on the versatility of oligonucleotides as potential therapeutics. Spanning a period of several decades, various other leads of research were undertaken, i.e. 2'- and 3'-amino or -azido-substituted deoxyribonucleoside analogs, hammerhead ribozymes, small non-coding mRNAs (siRNAs, miRNAs) for monitoring gene therapy, and thiophosphate-substituted nucleotide analogs to be used in RNA and DNA sequencing. This exemplary scientific career generated not one but a multitude of magic bullets for biomedical research and application.
期刊介绍：
Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids.
Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.
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