Clinical and parasitological efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) for the treatment of uncomplicated falciparum malaria in different transmission settings in India.
Ritesh Ranjha, Rajendra Baharia, Vani H Chalageri, Bina Srivastava, Naseem Ahmed, Supriya Sharma, Prashant Kumar Mallick, Anupkumar R Anvikar, Praveen Kumar Bharti
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Abstract
Background objectives: In 2010, artesunate and sulfadoxine-pyrimethamine (AS+SP) were adopted as the first-line artemisinin based combination therapy for treatment of uncomplicated Plasmodium falciparum malaria in India. Continuous therapeutic efficacy monitoring of firstline anti-malarial drugs is required to update the treatment policy for malaria control and elimination. This study aimed to assess the therapeutic efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) at three sites with different diseases transmission intensity.
Methods: A 28-day, single-arm, prospective study was conducted to evaluate the clinical and parasitological response to AS+SP. Patients received a six-dose regimen of AS+SP over three days and were monitored for 28 days through clinical and laboratory assessments. Participant recruitment and outcome classification was done as per the WHO guidelines for the surveillance of anti-malarial drug efficacy.
Results: A total of 170 participants were enrolled and 147 of them completed the follow-up. Adequate clinical and parasitological response (ACPR) was observed in 100% of the study participants who completed the follow-up. 100% fever clearance as well as parasite clearance was observed on day 3.
Interpretation conclusion: This study demonstrated high therapeutic efficacy and a good safety profile for artesunate and sulfadoxine-pyrimethamine at different transmission intensities. This suggests the continuation of the current artemisinin based combination therapy for the treatment of P. falciparum malaria in India.
期刊介绍：
National Institute of Malaria Research on behalf of Indian Council of Medical Research (ICMR) publishes the Journal of Vector Borne Diseases. This Journal was earlier published as the Indian Journal of Malariology, a peer reviewed and open access biomedical journal in the field of vector borne diseases. The Journal publishes review articles, original research articles, short research communications, case reports of prime importance, letters to the editor in the field of vector borne diseases and their control.
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