Depth-Dependent Color-Coded Optical Attenuation Coefficient Imaging: Assisted Examination Methods of Facial Microcirculation

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2025-05-13 DOI:10.1002/jbio.202500074

Jian Liu, Linghui Kong, Binyin Zhang, Yao Yu, Zhenhe Ma

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Abstract

This study investigates the relationship between facial microcirculation and optical parameters using swept-source optical coherence tomography (SS-OCT). Facial microcirculation deterioration impacts skin health by causing blood stagnation and metabolic disorders, influencing optical properties like scattering and attenuation. High-resolution SS-OCT imaging revealed distinct correlations between blood flow and optical attenuation coefficient (OAC) across skin layers: epidermal OAC showed a negative correlation with blood flow (r = −0.29 ± 0.03), while dermal OAC demonstrated a positive correlation (r = −0.43 ± 0.06). Leveraging this finding, we developed a depth-encoded color OAC imaging mode that enhances facial microcirculation visualization without additional scanning. The work provides mechanistic insights into microcirculation-related skin deterioration and establishes a novel clinical tool for diagnosing and managing associated conditions.

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深度相关彩色编码光学衰减系数成像：面部微循环辅助检查方法。

本研究利用扫描源光学相干断层扫描（SS-OCT）研究了面部微循环与光学参数的关系。面部微循环恶化通过引起血液停滞和代谢紊乱影响皮肤健康，影响散射和衰减等光学特性。高分辨率SS-OCT成像显示血流量与跨皮肤层光学衰减系数（OAC）有明显的相关性：表皮OAC与血流量呈负相关（r = -0.29±0.03），真皮OAC呈正相关（r = -0.43±0.06）。利用这一发现，我们开发了一种深度编码彩色OAC成像模式，无需额外扫描即可增强面部微循环可视化。这项工作为微循环相关的皮肤恶化提供了机制见解，并为诊断和管理相关疾病建立了一种新的临床工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.