Younger-onset type 2 diabetes associated with increased long-term cancer risk in Chinese adults: A 30-year follow-up of the Da Qing Diabetes Study.

BJC reports Pub Date : 2025-04-22 DOI:10.1038/s44276-025-00142-5

Siyao He, Xin Qian, Jinping Wang, Xiaoxia Shen, Yali An, Bo Zhang, Bo Chen, Hui Li, Xiaoping Chen, Yanyan Chen, Yang Wang, Chenggang Jin, Qiuhong Gong, Guangwei Li

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Abstract

Background: We investigated the association between younger-onset type 2 diabetes, duration of diabetes, and cancer risk based on data from the Da Qing Diabetes Prevention Outcome Study (DQDPOS).

Methods: The analysis recruited 620 younger-onset (age≤50 years) and 649 older-onset (age>50 years) patients with type 2 diabetes, and 310 younger non-diabetes controls (age≤50 years). Multiple regression analysis was used to test the influence of younger-onset diabetes and duration of diabetes on the long-term risk of cancer.

Results: The annual incidence of all cancer among the non-diabetes, younger-, and older-onset type 2 diabetes was significantly different (3.7, 5.5, and 4.0/1000 person-years, respectively). The standard Cox analysis revealed that the patients with younger-onset diabetes had a significantly higher risk of cancer than those with older-onset diabetes (hazard ratio [HR]:1.81; 95% confidence interval [CI]:1.20-2.73) and younger non-diabetic controls (HR:2.43; 95% CI:1.34-4.41) after adjustment for diabetes duration and other confounders. Stepwise general linear regression model analysis revealed that a longer diabetes-free time was associated with longer lifetime cancer-free years (partial R² = 0.36, p < 0.001), in addition to the non-modifiable predictor duration of diabetes.

Conclusions: Younger-onset type 2 diabetes was significantly associated with an increased risk of cancer beyond the influence of diabetes duration.

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中国成人年轻发病2型糖尿病与长期癌症风险增加相关：大庆糖尿病研究的30年随访

背景：我们基于大庆糖尿病预防结局研究（DQDPOS）的数据调查了年轻发病的2型糖尿病、糖尿病病程和癌症风险之间的关系。方法：本研究招募年龄≤50岁的年轻发病2型糖尿病患者620例，年龄≥50岁的老年发病2型糖尿病患者649例，年龄≤50岁的年轻非糖尿病对照310例。采用多元回归分析检验糖尿病发病年龄和糖尿病病程对癌症长期风险的影响。结果：非糖尿病、年轻发病和老年发病2型糖尿病患者的所有癌症年发病率有显著差异（分别为3.7、5.5和4.0/1000人年）。标准Cox分析显示，起病年龄较小的糖尿病患者发生癌症的风险明显高于起病年龄较大的糖尿病患者(危险比[HR]:1.81；95%可信区间[CI]:1.20-2.73)和年轻的非糖尿病对照组(HR:2.43；95% CI:1.34-4.41)，校正了糖尿病病程和其他混杂因素。逐步一般线性回归模型分析显示，较长的无糖尿病时间与较长的终生无癌年相关（部分R2 = 0.36, p）。结论：年轻发病的2型糖尿病与癌症风险增加显著相关，不受糖尿病病程的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BJC reports

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