Intestinal Metabolome for Diagnosing and Prognosing Autism Spectrum Disorder in Children: A Systematic Review.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-03-21 DOI:10.3390/metabo15040213

Andrés Suárez-Jaramillo, Sara G Cifuentes, Manuel Baldeón, Paúl Cárdenas

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引用次数: 0

Abstract

Background/Objectives: Currently, the diagnosis of autism spectrum disorder (ASD) relies on behavioral observations, frequently causing delays in early identification. Prognostic markers are essential for customizing therapy and monitoring progress. However, there are currently no recognized biomarkers for ASD. The current systematic review aims to analyze studies on the intestinal metabolome in children (both autistic and non-autistic) to identify potential metabolites for diagnostic and prognostic purposes. Methods: We searched Medline, Scopus, Embase, and Web of Science for relevant publications. Results: We identified 11 studies examining the gut metabolome that distinguished between autistic and non-autistic children. These studies also revealed connections between gut metabolites, developmental scores, and symptoms. The substances identified were associated with metabolic pathways such as amino acids, vitamins, lipids, oxidative stress, glycans, xenobiotics, and nucleotides. Conclusions: These findings suggest metabolic changes that may be linked to the causes or development of autism. Although these observations came from a few reports, only high-quality studies were included in this review. Further research is essential to confirm the identified substances as biomarkers.

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肠道代谢组对儿童自闭症谱系障碍的诊断和预后：系统综述。

背景/目的：目前，自闭症谱系障碍（ASD）的诊断依赖于行为观察，这往往导致早期识别的延迟。预后指标对于定制治疗和监测进展至关重要。然而，目前还没有公认的ASD生物标志物。本系统综述旨在分析儿童（包括自闭症和非自闭症）肠道代谢组的研究，以确定用于诊断和预后目的的潜在代谢物。方法：检索Medline、Scopus、Embase、Web of Science等相关文献。结果：我们确定了11项研究，这些研究检查了区分自闭症儿童和非自闭症儿童的肠道代谢组。这些研究还揭示了肠道代谢物、发育评分和症状之间的联系。鉴定的物质与代谢途径有关，如氨基酸、维生素、脂质、氧化应激、聚糖、异种生物和核苷酸。结论：这些发现表明，代谢变化可能与自闭症的起因或发展有关。虽然这些观察结果来自少数报告，但本综述只纳入了高质量的研究。进一步的研究是必要的，以确认已确定的物质作为生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.