Association of genetic variants of TCF7L2 gene with gestational diabetes mellitus.

Abstract

Gestational diabetes mellitus (GDM) is a metabolic disorder that poses significant risks during pregnancy. The TCF7L2 gene, previously linked to type 2 diabetes, has also been associated with GDM. This study investigated the frequency of TCF7L2 single nucleotide polymorphism (SNP) alleles and their correlation with metabolic parameters in women with GDM. The study, evaluated the TCF7L2 intron polymorphisms rs7903146 and rs11196205 in 45 GDM patients and 45 control pregnant females. GDM patients, with mean age of 30.5 ± 4.6 years, had lower sex hormone-binding globulin and serum magnesium levels than controls. The study found significant associations between GDM and both SNPs. For rs7903146, the TT genotype increased GDM risk by 19.6-fold, while the CT+TT genotypes increased the risk by 8.2-fold under the dominant genetic model. The T allele raised GDM risk by a factor of 9.3. For rs11196205, the GC and CC genotypes increased GDM risk by 12.6-fold and 10.7-fold, respectively. Under the dominant genetic model, the G/C or C/C genotypes increased GDM risk by 11.7-fold, and the C allele raised GDM risk by a factor of 8.9. In conclusion, compared to the control group, the GDM of the study individuals was substantially related to the (rs7903146) (T>C) and (rs11196205) C>G SNPs.