Development and characterization of quetiapine-loaded microneedles-based transdermal patches for improved drug delivery.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmacy and Pharmacology Pub Date : 2025-05-07 DOI:10.1093/jpp/rgaf013

Maryam Itbar, Muhammad Imran Khan, Muhammad Furqan Akhtar, Zulcaif Ahmad, Muhammad Farhan Sohail, Asadullah Madni, Alia Erum, Aslam Khan, Ahsan Ali, Muhammad Naeem Qaisar

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引用次数: 0

Abstract

Objectives: This study was executed to prepare and characterize quetiapine (antipsychotic drug)-loaded microneedles-based transdermal patch for improved drug delivery.

Methods: This study was executed to develop microneedles-based transdermal patches (MNS) for quetiapine delivery. Eight MNS patches loaded with quetiapine (MNS1-MNS8) were fabricated using varying concentrations of sodium alginate and carboxymethyl cellulose. First four MNS patches (MNS1, MNS2, MNS3, and MNS4) were prepared by keeping sodium alginate concentration constant (6%) and increasing CMC concentration from 3% to 6%, whereas MNS5, MNS6, MNS7, and MNS8 were developed using sodium alginate to CMC concentrations 7:3, 7:4, 8:3, and 8:4, respectively. Solvent casting technique was opted for preparation of MNS patches. MNS were characterized for thickness, folding endurance, insertion capacity, drug content, morphology, and ex-vivo permeation profile using Wistar rat skin.

Key findings: FTIR studies revealed the compatibility of quetiapine with formulation composites. Thickness and folding endurance was ranged in between 0.53-0.55 mm and 25-264, respectively. SEM of optimized patch showed sharp pointed needles. Ex-vivo permeation studies showed percent drug release of 84.34% from MNS1 after 48 h.

Conclusions: The overall findings of study proposed that the quetiapine-loaded MNS patches hold promise for the improved transdermal delivery of quetiapine.

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奎硫平微针透皮贴剂的开发与特性研究。

目的：本研究旨在制备和表征负载奎硫平（抗精神病药物）的微针透皮贴剂，以改善药物传递。方法：本研究旨在开发喹硫平微针透皮贴剂。用不同浓度的海藻酸钠和羧甲基纤维素制备了8个负载喹硫平的MNS贴片（MNS1-MNS8）。在保持海藻酸钠浓度不变（6%），CMC浓度从3%增加到6%的条件下，制备了MNS1、MNS2、MNS3和MNS4 4个MNS贴片，而在海藻酸钠与CMC浓度分别为7:3、7:4、8:3和8:4的条件下，制备了MNS5、MNS6、MNS7和MNS8。采用溶剂铸造技术制备MNS贴片。利用Wistar大鼠皮肤对MNS的厚度、折叠耐力、插入容量、药物含量、形态和离体渗透谱进行表征。主要发现：FTIR研究揭示了喹硫平与复合制剂的相容性。厚度在0.53 ~ 0.55 mm之间，折叠耐力在25 ~ 264 mm之间。优化后的贴片扫描电镜显示针尖锋利。体外渗透研究表明，48 h后MNS1的药物释放率为84.34%。结论：研究的总体结果表明，负载喹硫平的MNS贴片有望改善喹硫平的透皮给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacy and Pharmacology 医学-药学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.