Study of a single eye bank. Characteristics and progression of corneal transplantation from 2016 through 2022 in Galicia (Spain)

Archivos de la Sociedad Espanola de Oftalmologia Pub Date : 2025-05-01 DOI:10.1016/j.oftale.2025.04.005

L. Zurutuza-Veillet , M.A. Saavedra-García , M. Álvarez-Portela , J. Suanzes-Hernández

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Abstract

Objective

To describe the characteristics of donated and transplanted corneas, trends in surgical techniques, and indications for corneal transplantation, and the impact of COVID-19 on a Spanish tissue bank from 2016 through 2022.

Methods

We conducted a retrospective analysis of corneal donation records from Complejo Hospitalario Universitario de A Coruña Cryobiology Unit and Tissue Bank from January 1st, 2016 through June 30th, 2022.

Results

Corneal donations and transplants remained stable over 6.5 years, except for declines in 2020–2021. A total of 44.3% of all donated corneas were not transplanted, mainly due to tissue viability issues (41.4%). Donors averaged 60.2 ± 13 years, with a mean corneal endothelial cell count of 2701.3 ± 324.6 cells/mm² and a mean corneal clear zone diameter of 7.7 ± 0.7 mm. The preferred preservation method for keratoplasty was hypothermia (85,9%). Indications included endothelial dysfunction (53.8%), repeated keratoplasty (18.8%), corneal ectasia (15.4%), stromal opacity (7.6%), and tectonic causes (4.9%). Penetrating keratoplasty (PK) was more common (56.3%) than lamellar techniques (43.7%), but endothelial keratoplasty (EK) increased by 27.8% since 2019. EK, predominantly Descemet Membrane Endothelial Keratoplasty (DMEK, 94.1%), was used in 96.7% of endothelial dysfunction cases, although 28.6% were treated with PK. Deep anterior lamellar keratoplasty was primarily used for corneal ectasia (46.8%).

Conclusions

The Galicia Tissue Bank exceeds the European Eye Bank Association quality standards. Penetrating techniques remain predominant, but the trend is towards favor lamellar procedures, particularly DMEK. Endothelial dysfunction is the leading and growing indication for corneal transplantation.

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单一眼库的研究。加利西亚（西班牙）2016 - 2022年角膜移植的特点和进展

目的：了解2016 - 2022年西班牙某组织库角膜捐献与移植的特点、手术技术发展趋势、角膜移植适应证以及新冠肺炎疫情对组织库的影响。方法：回顾性分析2016年1月1日至2022年6月30日期间，a Universitario complexjo Hospitalario Coruña冷冻生物学单位和组织库的角膜捐赠记录。结果：除了2020-2021年下降外，角膜捐赠和移植在6.5年内保持稳定。共有44.3%的捐献角膜没有被移植，主要是由于组织活力问题（41.4%）。供者平均年龄60.2±13岁，平均角膜内皮细胞计数为2701.3±324.6个/mm²，平均角膜透明区直径为7.7±0.7 mm。首选保存角膜移植的方法是低温（85.9%）。适应症包括内皮功能障碍（53.8%）、反复角膜移植（18.8%）、角膜扩张（15.4%）、间质混浊（7.6%）和构造原因（4.9%）。穿透性角膜移植术（PK）比板层技术（43.7%）更常见（56.3%），但内皮性角膜移植术（EK）自2019年以来增加了27.8%。EK，主要是Descemet膜内皮角膜移植术（DMEK, 94.1%），用于96.7%的内皮功能障碍病例，尽管28.6%的患者接受了PK治疗。深前板层角膜移植术主要用于角膜扩张（46.8%）。结论：加利西亚组织库超过了欧洲眼库协会的质量标准。穿透技术仍然占主导地位，但趋势是有利于层状工艺，特别是DMEK。内皮功能障碍是角膜移植的主要和日益增长的适应症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archivos de la Sociedad Espanola de Oftalmologia

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