Life History-Dependent Brain Transcriptomic Signatures in Nothobranchids: Insights into Aging, Neurogenesis, and Life History Evolution.

IF 2.2 4区生物学 Q2 BIOLOGY

Integrative Organismal Biology Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI:10.1093/iob/obaf016

C J Leow, K R Piller

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Abstract

The African turquoise killifish Nothobranchius furzeri is a powerful model organism in aging research. Within the family Nothobranchiidae, a wide range of lifespan is observed in annual, semi-annual, and non-annual life histories. In this study, we examined the brain transcriptomic signatures of adult nothobranchids across life history variations. Our results show that the brain gene expression profiles exhibit strong life history signatures compared to the liver tissue. Semi-annual Fundulopanchax species shows upregulation in cell division and mitosis compared to non-annual Aphyosemion species. We identified genes related to neurogenesis such as DNMT3A, SOX2, and FGF10 that show downregulation in the short-lived annual species compared to other life histories. The Notch signaling pathway is enriched in the non-annual species suggesting the importance of this pathway in longer-lived killifish. Our study demonstrates that other non-model nothobranchids can be used as comparative species to N . furzeri in the study of aging, neurogenesis, and life history.

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Nothobranchids的生活史依赖的脑转录组特征：对衰老、神经发生和生活史进化的见解。

非洲绿松石鳉（Nothobranchius furzeri）是衰老研究中一种强有力的模式生物。在Nothobranchiidae家族中，在一年生、半年生和非一年生的生活史中观察到的寿命范围很广。在这项研究中，我们研究了跨越生活史变化的成年无分枝鱼的脑转录组特征。我们的研究结果表明，与肝组织相比，大脑基因表达谱表现出强烈的生活史特征。与非一年生的葡萄属植物相比，半年生的Fundulopanchax在细胞分裂和有丝分裂方面表现出上调。我们发现了与神经发生相关的基因，如DNMT3A、SOX2和FGF10，与其他生活史相比，这些基因在短命的一年生物种中表现出下调。Notch信号通路在非一年生物种中丰富，这表明该通路在长寿的鳉鱼中很重要。我们的研究表明，其他非模式nothobranchids可以作为N的比较种。在衰老，神经发生和生命史的研究中。

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