Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges.

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI:10.1080/17435889.2025.2501919

Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito

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Abstract

Different cancers remain major global health challenges due to their diverse biological behaviors and significant treatment hurdles. The aging of populations and lifestyle factors increase cancer occurrence and place increasing pressure on healthcare systems. Despite continuous advancements, many cancers remain fatal due to late-stage diagnosis, tumor heterogeneity, and drug resistance, thus necessitating urgent development of innovative treatment solutions. Therapeutic nucleic acids, a new class of biological drugs, offer a promising approach to overcoming these challenges. The recent Nucleic Acids and Nanobiosystems in Cancer Theranostics (NANCT) conference brought together internationally recognized experts from 15 countries to discuss cutting-edge research, spanning from oncolytic viruses to anticancer RNA nanoparticles and other emerging nanotechnologies. This review captures key insights and developments, emphasizing the need for interdisciplinary translation of scientific advancements into clinical practice and shaping the future of personalized cancer treatments for improved therapeutic outcomes.

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用于癌症治疗的核酸纳米生物系统：新兴趋势和挑战的概述。

不同的癌症由于其不同的生物学行为和重大的治疗障碍，仍然是主要的全球健康挑战。人口老龄化和生活方式因素增加了癌症的发病率，并给医疗保健系统带来了越来越大的压力。尽管不断取得进展，但由于晚期诊断、肿瘤异质性和耐药性，许多癌症仍然是致命的，因此迫切需要开发创新的治疗方案。治疗性核酸是一类新的生物药物，为克服这些挑战提供了一种有希望的方法。最近召开的癌症治疗学中的核酸和纳米生物系统（NANCT）会议汇集了来自15个国家的国际知名专家，讨论了从溶瘤病毒到抗癌RNA纳米粒子和其他新兴纳米技术的前沿研究。这篇综述抓住了关键的见解和发展，强调了将科学进步跨学科转化为临床实践的必要性，并塑造了个性化癌症治疗的未来，以改善治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanomedicine (London, England)

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