The contribution of prolactin in the occurrence of premature cardiovascular disease predominantly through modulating the inflammatory cascade.

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2025-04-21 DOI:10.1111/eci.70042

Lisa Kamperdijk, Nikol Shkarpa, Marcel Th B Twickler

引用次数: 0

Abstract

Cardiovascular disease, mainly coronary atherothrombosis, is an essential contributor to all-cause mortality, accounting for approximately 30% of all global deaths. Imbalances in hormone profiles may play a role in the evolution of atherothrombosis. In the last decade, our clinical research focused on the hormone prolactin (PRL) and its contribution to premature cardiovascular disease. In this narrative review, we aimed to give current insights into how PRL could modulate the inflammatory cascade within the microenvironment of the atherosclerotic plaque, which could lead to increased cardiovascular morbidity and mortality.

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催乳素在早发性心血管疾病发生中的作用主要通过调节炎症级联反应。

心血管疾病，主要是冠状动脉粥样硬化血栓形成，是造成全因死亡的一个重要因素，约占全球所有死亡人数的30%。激素谱失衡可能在动脉粥样硬化血栓形成的演变中起作用。在过去的十年中，我们的临床研究主要集中在激素催乳素（PRL）及其对过早心血管疾病的贡献。在这篇叙述性综述中，我们的目的是为PRL如何调节动脉粥样硬化斑块微环境中的炎症级联反应提供当前的见解，这可能导致心血管发病率和死亡率的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.