Amelioration of convulsion-induced depression comorbidity by Rubus ellipticus whole plant extract in experimental models.

IF 1.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI:10.4103/ijp.ijp_215_23

Suniti Chand, Saumya Das, Avijit Mazumder, Swarupanjali Padhi, Chandana Majee, Ananya Pandey, Manas Kumar Das

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Abstract

Abstract: Neuropsychiatric disorders are widespread and serious and have a detrimental effect on the patient's physical and mental health. The aim of the present study was to find the protective effect of Rubus ellipticus in epilepsy by maximal electroshock seizure, pentylenetetrazol, and related depressive behavior by Forced Swim Test and Tail Suspension Test. The animals were given ethanol extract of R. ellipticus (EERE) (100, 200, or 400 mg/kg) doses for 10 days. On every 5th day, seizure monitoring was performed (day 5 and day 10), followed by depressive behavior monitoring by evaluating immobility time. It was revealed that EERE treatment caused antidepressive-like behavior as a comorbid antiepileptogenic effect. This study will provide compelling evidence to support further clinical trials to grow this medicinal plant in the management of epileptogenic and associated debilitating behavioral comorbidities.

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野荆芥全植物提取物改善惊厥性抑郁合并症的实验模型。

摘要：神经精神疾病是一种广泛而严重的疾病，严重影响着患者的身心健康。本研究通过强迫游泳试验和悬尾试验，探讨椭圆圆草对最大电休克癫痫发作、戊四唑及相关抑郁行为的保护作用。小鼠分别给予100、200、400 mg/kg剂量的椭圆圆草乙醇提取物（EERE） 10天。每隔5天进行一次癫痫发作监测（第5天和第10天），随后通过评估静止时间进行抑郁行为监测。结果表明，EERE治疗引起抗抑郁样行为是一种共病的抗癫痫作用。这项研究将提供令人信服的证据，支持进一步的临床试验，将这种药用植物种植在癫痫性和相关的衰弱行为合并症的管理中。

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来源期刊

Indian Journal of Pharmacology 医学-药学

CiteScore

4.00

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Pharmacology accepts, in English, review articles, articles for educational forum, original research articles (full length and short communications), letter to editor, case reports and interesting fillers. Articles concerning all aspects of pharmacology will be considered. Articles of general interest (e.g. methods, therapeutics, medical education, interesting websites, new drug information and commentary on a recent topic) are also welcome.