Prevalence of peripheral neuropathy in Egyptian Psoriatic Arthritis Patients and its correlation with disease activity.

IF 3.9 3区医学 Q2 IMMUNOLOGY

Expert Review of Clinical Immunology Pub Date : 2025-04-21 DOI:10.1080/1744666X.2025.2495170

MennaAllah Mohamed Ali Elmalla, Hanaa Ahmad Samy Elbanna, Manal Shawky Hussein Sayed Ahmed, Amira Mohamed El Sharkawy

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Abstract

Introduction: Peripheral neuropathy (PN) may arise from various etiologies, including immune-mediated diseases.This study aimed to detect the prevalence and clinical determinants of PN in psoriatic arthritis (PsA) patients, with or without skin lesions, and to evaluate its correlation with disease activity.

Research design and methods: This cross sectional study included 60 PsA patients and 60 apparently healthy controls. Neuropathic pain was evaluated using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) score, while PN was assessed through the Michigan Neuropathy Screening Instrument (MNSI), in conjunction with electrophysiological assessment.

Results: The LANSS score demonstrated the capability to predict neuropathic pain in PsA patients with a sensitivity of 93.89% and specificity of 83.33%. Furthermore, the MNSI Questionnaire score revealed a sensitivity of 91.67% and specificity of 77.78% in predicting PN among PsA patients. Carpal tunnel syndrome represented the most prevalent neuropathy identified in 36% of PsA patients, followed by peripheral polyneuropathy in 6%, and ulnar neuropathy in 4%.

Conclusions: Patients with PsA have higher prevalence of neuropathy, particularly carpal tunnel syndrome, which negatively impacts pain perception, functional capability, and quality of life, particularly in those with higher disease activity suggesting potential association between inflammation and neurological dysfunction.

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埃及银屑病关节炎患者周围神经病变的患病率及其与疾病活动度的相关性

周围神经病变（PN）可能由多种病因引起，包括免疫介导的疾病。本研究旨在检测有或无皮肤病变的银屑病关节炎（PsA）患者PN的患病率和临床决定因素，并评估其与疾病活动性的相关性。研究设计和方法：本横断面研究包括60例PsA患者和60例表面健康对照。使用利兹神经性疼痛症状和体征评估（LANSS）评分评估神经性疼痛，而通过密歇根神经病变筛查仪器（MNSI）评估PN，并结合电生理评估。结果：LANSS评分预测PsA患者神经性疼痛的敏感性为93.89%，特异性为83.33%。MNSI问卷评分预测PsA患者PN的敏感性为91.67%，特异性为77.78%。在36%的PsA患者中，腕管综合征是最常见的神经病变，其次是6%的周围多神经病变和4%的尺神经病变。结论：PsA患者有较高的神经病变患病率，特别是腕管综合征，这对疼痛感知、功能能力和生活质量产生负面影响，特别是在那些疾病活动度较高的患者中，这表明炎症和神经功能障碍之间存在潜在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.