The Power of Antibodies: Advancing Biomarker-Based Disease Detection and Surveillance.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Immunological Investigations Pub Date : 2025-04-21 DOI:10.1080/08820139.2025.2492246

Woei Kean Ng, Gunasegran Thanusha, Pei Pei Chong, Candy Chuah

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引用次数: 0

Abstract

Background: Antibodies have long served as fundamental tools in disease diagnosis and surveillance. Their utility as biomarkers has expanded beyond infectious diseases to encompass a wide range of health conditions.

Objectives: This review aims to explore recent advancements in antibody biomarker discovery and their applications in diagnosing and monitoring diverse health conditions. It also examines the role of antibody surveillance in public health and epidemiological studies.

Methods: A comprehensive analysis of recent literature was conducted, focusing on studies that identify and characterize disease-specific antibodies. Particular attention was given to their relevance in autoimmune diseases, infections, cancers, and neurological disorders.

Content: The review highlights disease-specific antibody biomarkers and their clinical significance. It also discusses the utility and challenges of antibody-based surveillance in assessing disease prevalence, tracking immunity trends, and supporting One Health strategies.

Conclusions: Recent advancements in antibody biomarker discovery demonstrate significant potential in improving early diagnosis, personalized treatment, and population-level health management. Antibody surveillance continues to play a pivotal role in guiding public health responses and understanding disease dynamics.

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抗体的力量：推进基于生物标志物的疾病检测和监测。

背景：抗体长期以来一直是疾病诊断和监测的基本工具。它们作为生物标志物的用途已经从传染病扩展到广泛的健康状况。目的：综述抗体生物标志物的发现及其在多种健康状况诊断和监测中的应用进展。它还审查了抗体监测在公共卫生和流行病学研究中的作用。方法：对近期文献进行综合分析，重点研究疾病特异性抗体的鉴定和表征。特别关注它们在自身免疫性疾病、感染、癌症和神经系统疾病中的相关性。内容：综述了疾病特异性抗体生物标志物及其临床意义。它还讨论了基于抗体的监测在评估疾病流行、跟踪免疫趋势和支持“同一个健康”战略方面的效用和挑战。结论：抗体生物标志物的最新发现显示了在改善早期诊断、个性化治疗和人群健康管理方面的巨大潜力。抗体监测在指导公共卫生反应和了解疾病动态方面继续发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunological Investigations 医学-免疫学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.