Mild motor signs and depression: more than just medication side effects?

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-04-25 DOI:10.1007/s00406-025-02015-x

Antonina Luca, Maria Luca, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Raffaele Zanardi, Raffaella Ferri, Bartolo Lanuzza, Basilio Pecorino, Bernhard T Baune, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti

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引用次数: 0

Abstract

The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs in 790 patients with MDD were correlated with treatment outcome. Three hundred ten (39.2%) were responders and 480 (60.8%) were non-responders. 342 (43.3%) presented neurological signs. In the whole sample negative associations between dystonia and rigidity and various medications was observed. Non-response was associated with dystonia, rigidity, and hypokinesia independent from age and medications. This study highlighted an association between MMS and specific medications. Moreover, MMS were associated with non-response to treatment, regardless of medication use. This may suggest that a subgroup of patients with MDD may respond less to therapy because of an underlying still undetected neurological disorder.

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轻度运动症状和抑郁：不仅仅是药物副作用？

重度抑郁障碍（MDD）与轻度运动体征（MMS）之间的关系仍有待阐明。本研究旨在评估神经系统症状与药物和治疗反应之间的关系。790例重度抑郁症患者的神经系统症状与治疗结果相关。应答者310例（39.2%），无应答者480例（60.8%）。342例（43.3%）出现神经学症状。在整个样本中，观察到肌张力障碍和僵硬与各种药物之间的负相关。无反应与肌张力障碍、强直和运动障碍相关，与年龄和药物无关。这项研究强调了MMS与特定药物之间的联系。此外，无论使用何种药物，MMS均与治疗无反应相关。这可能表明，由于潜在的尚未被发现的神经系统疾病，一个亚组的重度抑郁症患者可能对治疗反应较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.