Characteristics and hemolysis analysis of centrifugal blood pumps under different speed modulations.

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1575971

Chengxuan Su, Donghai Jin, Guangmao Liu, Shulei Li, Xingmin Gui

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引用次数: 0

Abstract

Introduction: Constant-speed methods are widely applied and studied in rotary blood pumps. However, various speed modulation which have been used in commercial blood pump lacks validation of the ventricular assist capability and hemolysis potential.

Methods: This study investigates the hydrodynamic performance and hemolysis of a rotary ventricular assist device under sinusoidal speed modulation, focusing on the combined effects of phase, baseline speed, and speed fluctuation amplitude.

Results: Computational fluid dynamics (CFD) coupled with a dynamic cardiovascular model revealed that counter-phase modulation reduces hemolysis index (HI) fluctuations compared to in-phase conditions, while higher baseline speeds increase time-averaged HI due to prolonged exposure to non-physiological shear stress. Larger amplitudes expand the operational range but exacerbate HI variability.

Discussion: These findings demonstrate that phase synchronization critically balances pulsatility and hemocompatibility, providing actionable insights for adaptive speed control strategies in clinical practice.

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不同转速下离心血泵特性及溶血分析。

恒速法在旋转血泵中得到了广泛的应用和研究。然而，目前在商用血泵中使用的各种调速装置，缺乏对其心室辅助能力和溶血潜能的验证。方法：研究正弦速度调制下旋转心室辅助装置的流体动力性能和溶血情况，重点研究相位、基线速度和速度波动幅度的联合影响。结果：计算流体动力学（CFD）与动态心血管模型相结合表明，与相态条件相比，反相位调制降低了溶血指数（HI）波动，而较高的基线速度由于长时间暴露于非生生性剪切应力而增加了时间平均HI。较大的振幅扩大了操作范围，但加剧了HI变异性。讨论：这些研究结果表明，相同步可以平衡脉搏和血液相容性，为临床实践中的自适应速度控制策略提供可操作的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.