Association of Obesity, Visceral Fat Accumulation, and Dyslipidemia with the Risk of Chronic Kidney Disease.

IF 1.1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI:10.2169/internalmedicine.4613-24
Yui Yoshida, Yasuhiro Hagiwara, Mari Ito, Hiroshi Nishi, Yutaka Matsuyama
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引用次数: 0

Abstract

Objective Although chronic kidney disease (CKD) is independently associated with hypertension or hyperglycemia, there is no consensus on the thresholds of obesity, dyslipidemia, or visceral fat accumulation to predict CKD onset and progression. Methods We performed a multivariable logistic regression analysis for the association of the subsequent rate of estimated glomerular filtration rate (eGFR) decline with body mass index (BMI), blood high-density lipoprotein (HDL) cholesterol and triglycerides (TG) levels on 308,174 subjects who underwent health examinations conducted by the Public Health Research Center Foundation from 2015 to 2022. In addition, a Poisson regression analysis was used to evaluate the association between the appearance of urinary protein in participants without baseline urinary protein levels and eGFR decline. Results The median age of the subjects was 46 years old, and the median observation period was approximately 3 years. An eGFR decline rate of ≥5%/year was significantly associated with low HDL-cholesterol levels (<40 mg/dL), independent of the BMI and TG levels. A high baseline BMI (≥25 kg/m2) or waist circumference (≥85 cm for men and ≥90 cm for women), high TG levels (≥150 mg/dL), and low HDL-cholesterol levels were significantly associated with new-onset proteinuria. Furthermore, the higher the baseline BMI, the higher the incidence rate ratio of new-onset proteinuria. Conclusion Independent of hyperglycemia and hypertension, dyslipidemia according to the Japanese metabolic syndrome criteria and an elevated BMI were associated with a high risk of new-onset proteinuria, and a low HDL-cholesterol level was significantly associated with a rapid eGFR decline.

肥胖、内脏脂肪堆积和血脂异常与慢性肾脏疾病风险的关系
虽然慢性肾脏疾病(CKD)与高血压或高血糖独立相关,但对于肥胖、血脂异常或内脏脂肪积累的阈值预测CKD的发生和进展尚无共识。方法对2015年至2022年接受公共卫生研究中心基金会健康检查的308174名受试者进行多变量logistic回归分析,以估计肾小球滤过率(eGFR)下降的后续率与体重指数(BMI)、血液高密度脂蛋白(HDL)胆固醇和甘油三酯(TG)水平的关系。此外,使用泊松回归分析来评估无基线尿蛋白水平的参与者的尿蛋白外观与eGFR下降之间的关系。结果受试者年龄中位数为46岁,观察时间中位数约为3年。eGFR下降率≥5%/年与低hdl -胆固醇水平(2)或腰围(男性≥85 cm,女性≥90 cm)、高TG水平(≥150 mg/dL)、低hdl -胆固醇水平与新发蛋白尿显著相关。此外,基线BMI越高,新发蛋白尿的发生率越高。结论与高血糖和高血压无关,符合日本代谢综合征标准的血脂异常和BMI升高与新发蛋白尿的高风险相关,低hdl -胆固醇水平与eGFR快速下降显著相关。
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来源期刊
Internal Medicine
Internal Medicine 医学-医学:内科
CiteScore
1.90
自引率
8.30%
发文量
0
审稿时长
2.2 months
期刊介绍: Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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