Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

IF 2.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2025-05-03 DOI:10.1016/j.amjmed.2025.04.034

Seung-Kwon Myung, Yunseo Park

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引用次数: 0

Abstract

Background: Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.

Methods: PubMed, Embase, and Cochrane Library were searched from inception to June 14, 2024.

Results: A total of 23 RCTs with 1474 participants were analyzed. In a meta-analysis of all 23 RCTs, collagen supplements significantly improved skin hydration, elasticity, and wrinkles. However, in the subgroup meta-analysis by funding source, studies not receiving funding from pharmaceutical companies revealed no effect of collagen supplements for improving skin hydration, elasticity, and wrinkles, while those receiving funding from pharmaceutical companies did show significant effects. Similarly, high-quality studies revealed no significant effect in all categories, while low-quality studies revealed a significant improvement in elasticity.

Conclusions: There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.

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胶原蛋白补充剂对皮肤衰老的影响：随机对照试验的系统回顾和荟萃分析。

背景：胶原蛋白补充剂被提倡来帮助老化的皮肤。然而，没有随机对照试验（RCTs）的荟萃分析通过资金来源和研究质量来检验它们的影响，这可能会影响结果。方法：检索PubMed、Embase和Cochrane图书馆自成立至2024年6月14日的文献。结果：共分析23项随机对照试验，1474名受试者。在对所有23项随机对照试验的荟萃分析中，胶原蛋白补充剂显著改善了皮肤的水合作用、弹性和皱纹。然而，在按资金来源进行的亚组荟萃分析中，没有得到制药公司资助的研究显示胶原蛋白补充剂对改善皮肤水合、弹性和皱纹没有效果，而那些得到制药公司资助的研究确实显示出显著的效果。同样，高质量的研究显示在所有类别中没有显著的效果，而低质量的研究显示弹性有显著的改善。结论：目前没有临床证据支持使用胶原蛋白补充剂来预防或治疗皮肤老化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.