Evaluation of Auditory Evoked Potentials in Neuromyelitis Optica Spectrum Disorder.

IF 2.5 4区医学 Q3 NEUROSCIENCES

Journal of integrative neuroscience Pub Date : 2025-04-22 DOI:10.31083/JIN27733

Lucas Pinto Mielle, Liliane Aparecida Fagundes Silva, Dayane Aparecida Nascimento Barbosa, Glauciene Amaral Martins, Alessandra Giannella Samelli, Carla Gentile Matas

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引用次数: 0

Abstract

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a recurrent demyelinating neuroinflammatory disorder of the central nervous system. This study aimed to evaluate the neural conduction and sound information processing in individuals with NMOSD, through the analysis of auditory brainstem responses (ABRs) and cortical auditory evoked potentials (CAEPs).

Methods: Twenty-four individuals (9-21 years old) were distributed into two groups: the study group (SG), diagnosed with NMOSD, and the control group, healthy individuals. Their ABRs and CAEPs were evaluated, and the results were examined alongside data from cranial magnetic resonance imaging (MRI).

Results: Abnormal ABRs were observed in 33% of the SG and increased I-III interpeak was the most prevalent finding. The CAEPs showed abnormalities in 58% of the SG, mainly to P1 latency. SG subjects presented longer P1, N1, and N2 latencies and lower N2-P3 amplitude. MRI showed alterations mostly in the pons, midbrain, and IV ventricle.

Conclusions: Alterations in neural conduction and sound information processing were observed in individuals with NMOSD when compared with their peers. Auditory evoked potentials are important instruments to identify central auditory dysfunction in this population as well as to monitor disease evolution.

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视神经脊髓炎谱系障碍的听觉诱发电位评价。

背景：视神经脊髓炎谱系障碍（NMOSD）是一种复发性脱髓鞘中枢神经系统神经炎症性疾病。本研究旨在通过听觉脑干反应（ABRs）和皮层听觉诱发电位（CAEPs）分析NMOSD个体的神经传导和声音信息加工。方法：24例（9 ~ 21岁）患者分为两组：研究组（SG）诊断为NMOSD，对照组为健康个体。评估他们的abr和caep，并将结果与颅磁共振成像（MRI）数据一起进行检查。结果：33%的SG出现abr异常，以I-III峰间增高最为常见。CAEPs显示58%的SG异常，主要与P1潜伏期有关。SG组的P1、N1和N2潜伏期较长，N2- p3振幅较低。MRI显示改变主要发生在脑桥、中脑和第四脑室。结论：与同龄人相比，NMOSD患者的神经传导和声音信息处理发生了改变。听觉诱发电位是识别该人群中枢性听觉功能障碍以及监测疾病演变的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of integrative neuroscience 医学-神经科学

CiteScore

2.80

自引率

5.60%

发文量

173

审稿时长

2 months

期刊介绍： JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.