Association between triglyceride-glucose index and the risk of type 2 diabetes mellitus.

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Archives of Endocrinology Metabolism Pub Date : 2025-04-15 DOI:10.20945/2359-4292-2023-0493

Hui Luo, Qin Yang, Haolan Xu, Shan Wu, Wenjing Wang, Ru Zhou, Yanlang Yang, Qi Yu

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引用次数: 0

Abstract

Objective: To assess the efficacy of the triglyceride-glucose (TyG) index in predicting type 2 diabetes mellitus (T2DM) in the general population.

Subjects and methods: Baseline data were collected from a community population that underwent physical examination between 2015 and 2020. The TyG index was calculated via the following formula: TyG = Ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. Cox regression and stratified analyses were performed to evaluate the ability of the TyG score to predict the occurrence of diabetes.

Results: In total, 8 576 subjects were ultimately included and divided into a T2DM group (n = 882) and a non-T2DM group (n = 7,694) according to the results of the 5-year follow-up. Adjustment for all covariates revealed that every 1-unit increase in the TyG index multiplied the risk of T2DM in all the participants (HR: 3.348; 95% CI: 3.004-3.731; P < 0.001). When TyG was divided into three quantiles, the risk of T2DM in the highest quantile was 6.412 times greater than that in the lowest quantile. Subgroup analysis revealed that the correlation was more pronounced in middle-aged and young adults, females, and eutrophic individuals (interaction P value < 0.001).

Conclusion: The TyG index can be a strong predictor of T2DM and is more useful for estimating the risk of T2DM in young and middle-aged adults, females, and eutrophic people.

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甘油三酯-葡萄糖指数与2型糖尿病风险的关系

目的：评价甘油三酯-葡萄糖（TyG）指数对普通人群2型糖尿病（T2DM）的预测作用。研究对象和方法：基线数据收集自2015年至2020年间接受体检的社区人群。TyG指数计算公式为：TyG = Ln[空腹甘油三酯（mg/dL） ×空腹血糖(mg/dL)/2]。采用Cox回归和分层分析来评估TyG评分预测糖尿病发生的能力。结果：最终共纳入8 576例受试者，根据5年随访结果分为T2DM组（n = 882）和非T2DM组（n = 7694）。所有协变量的调整显示，TyG指数每增加1个单位，所有参与者患T2DM的风险就增加一倍(HR: 3.348；95% ci: 3.004-3.731；P < 0.001)。将TyG分为三个分位数时，最高分位数的T2DM风险是最低分位数的6.412倍。亚组分析显示，相关性在中青年、女性和富营养化个体中更为明显（相互作用P值< 0.001）。结论：TyG指数是T2DM的一个强有力的预测指标，对于估计中青年、女性和富营养化人群的T2DM风险更有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

7 weeks

期刊介绍： The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.