Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study.

IF 4.9 2区 医学 Q1 Medicine
Sleep Pub Date : 2025-09-09 DOI:10.1093/sleep/zsaf089
Daisy Duan, Luu V Pham, Jonathan C Jun, Ruth-Alma Turkson-Ocran, Scott J Pilla, Jeanne M Clark, Nisa M Maruthur
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引用次数: 0

Abstract

Study objectives: Time-restricted eating (TRE) is a novel dietary intervention targeting weight loss and cardiometabolic risk factors. The impact of TRE on sleep patterns remains under-explored.

Methods: This was a post hoc analysis of a parallel-arm, controlled feeding trial in 41 adults with obesity and prediabetes/diabetes, randomized to TRE (08:00 am-06:00 pm) or usual eating pattern (UEP; 08:00 am-12:00 am) for 12 weeks. We objectively determined sleep-wake patterns from 7-day wrist actigraphy data obtained at baseline and week 12. From this data, we derived total sleep time (TST) and sleep midpoint over a 24-hour period, sleep onset/offset, and sleep continuity measures. We used paired t-tests or Wilcoxon signed rank tests to compare data between baseline and week 12 within intervention arms and Mann-Whitney U tests or Wilcoxon signed rank tests to compare changes between intervention arms.

Results: 38 participants (20 UEP; 18 TRE; 93% of those randomized in the parent trial) with adequate actigraphy data (mean age 59.6 ± 7.3 years, 92% female, 92% Black, mean BMI 36.3 ± 4.7 kg/m2) were analyzed. Compared to UEP, TRE increased TST by 55 minutes (p = .03). TRE shifted sleep midpoint to 44 minutes earlier, from 03:24 am to 02:40 am (p = .01), while UEP maintained the same sleep midpoint at 03:15 am. Sleep onset shifted from a median of 12:22 am to 11:52 pm in TRE (p = .03) while it remained stable in UEP (p = .97). There were no differences in sleep offset and sleep continuity within and between intervention arms.

Conclusions: TRE increased sleep time and caused earlier sleep onset compared to UEP, revealing how the timing of eating may affect sleep timing and duration.

Clinical trial: The Time Restricted Intake of Meals Study (TRIM). URL: https://clinicaltrials.gov/study/NCT03527368?tab=history&a=4.

Registration: NCT03527368.

限时进食对活动图衍生睡眠参数的影响:随机等热量进食研究的事后分析。
研究目的:限时饮食(TRE)是一种针对减肥和心脏代谢危险因素的新型饮食干预。TRE对睡眠模式的影响仍未得到充分研究。方法:这是一项对41名肥胖和前驱糖尿病/糖尿病成年人进行的平行对照喂养试验的事后分析,随机分为TRE(上午8点至下午6点)或常规饮食模式(UEP;8点到12点),持续12周。我们从基线和第12周获得的7天腕部活动记录仪数据客观地确定睡眠/觉醒模式。从这些数据中,我们得出了24小时内的总睡眠时间(TST)和睡眠中点,睡眠开始/偏移和睡眠连续性测量。我们使用配对t检验或Wilcoxon符号秩检验来比较干预组内基线和第12周的数据,使用Mann-Whitney U检验或Wilcoxon符号秩检验来比较干预组之间的变化。结果:38名受试者(20 UEP;18混乱关系;在父母试验中随机分配的具有足够活动记录数据的患者中(平均年龄59.6±7.3岁,92%为女性,92%为黑人,平均BMI为36.3±4.7 kg/m2),有93%进行了分析。与UEP相比,TRE使TST延长55分钟(p=0.03)。TRE将睡眠中点提前44分钟,从3:24am提前至2:40am (p=0.01),而UEP将相同的睡眠中点保持在3:15am。睡眠开始的中位数在TRE组从12:22am转移到11:52pm (p=0.03),而在UEP组保持稳定(p=0.97)。干预组内部和干预组之间的睡眠偏移和睡眠连续性没有差异。结论:与UEP相比,TRE增加了睡眠时间,导致了更早的睡眠开始,揭示了进食时间如何影响睡眠时间和持续时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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