{"title":"<i>ARL15</i> Gene Variant rs255758 Provides Susceptibility to Rheumatoid Arthritis in Northwest Indian Population.","authors":"Inder Mohan Singh Sandhu, Hemender Singh, Simranpreet Kaur, Ekta Rai, Anupama Mahajan, Gurinder Mohan, Swarkar Sharma","doi":"10.4103/ijabmr.ijabmr_156_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory autoimmune disease with a strong genetic component. <i>ARL15</i> gene variant rs255758 has been reported as a candidate for RA susceptibility. A replication study was performed on this variant by taking 188 RA cases and 310 healthy non-RA controls from northwest India in a case-control association study design.</p><p><strong>Materials and methods: </strong>DNA isolated from collected blood samples was analyzed by genotyping of the variant on real-time polymerase chain reaction using TaqMan Allele Discrimination Assay and statistically analyzed.</p><p><strong>Results: </strong>The variant was found to follow Hardy-Weinberg Equilibrium (<i>P</i> = 0.079) in the control group. The variant was significantly associated with RA susceptibility in the present studied population cohort (<i>P</i> = 0.024) with <i>C</i> as a risk allele and increased risk in the recessive model (<i>CC</i> vs. <i>CA</i> + <i>AA</i>; <i>P</i> = 0.004).</p><p><strong>Conclusion: </strong>The present study corroborates the earlier findings on the role of <i>ARL15</i> gene variant rs255758 in RA and further contributes to its genetic etiology.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 1","pages":"38-42"},"PeriodicalIF":0.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054651/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Applied and Basic Medical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijabmr.ijabmr_156_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory autoimmune disease with a strong genetic component. ARL15 gene variant rs255758 has been reported as a candidate for RA susceptibility. A replication study was performed on this variant by taking 188 RA cases and 310 healthy non-RA controls from northwest India in a case-control association study design.
Materials and methods: DNA isolated from collected blood samples was analyzed by genotyping of the variant on real-time polymerase chain reaction using TaqMan Allele Discrimination Assay and statistically analyzed.
Results: The variant was found to follow Hardy-Weinberg Equilibrium (P = 0.079) in the control group. The variant was significantly associated with RA susceptibility in the present studied population cohort (P = 0.024) with C as a risk allele and increased risk in the recessive model (CC vs. CA + AA; P = 0.004).
Conclusion: The present study corroborates the earlier findings on the role of ARL15 gene variant rs255758 in RA and further contributes to its genetic etiology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
