Volumetric and diffusion MRI longitudinal patterns in brain metastases after laser interstitial thermal therapy.

Abstract

Objective: To characterize MRI changes of brain metastases (BM) following laser interstitial thermal therapy (LITT), particularly in lesions exhibiting durable response or early progression.

Materials and methods: Longitudinal scans from patients with LITT-treated BM were retrospectively analyzed. Treatment response was categorized as durable response, long-term disease control (i.e., stable at 1 year), stable disease < 1 year, or progression < 1 year. Volumetric and diffusion MRI changes after LITT were analyzed for each subregion (contrast-enhancing, central non-enhancing, whole lesion). Volumetric changes were modeled with bi-exponential fits in responding lesions and progressors.

Results: 295 MRI scans from 47 lesions across 42 patients (57.8 ± 14.3 years old, males:females 21:21) were analyzed. Overall, the post-LITT scan showed a lesion enlargement (p < 0.0001 for all subregions), more pronounced in the contrast-enhancing (CE) component (median = +77%, p < 0.0001), and a reduction in the apparent diffusion coefficient (ADC) (p < 0.001), especially in the central non-CE component (median = -224 × 10^-6 mm²/s, p < 0.0001), with no significant differences between responders and progressors. Based on mathematical modeling, the responding lesions shrank to half of the post-LITT size after 79.83 days (median "pseudo-half-life"), and the progressing lesions shrank for a median of 27 days (median time-to-growth) before regrowing. The estimated optimal timepoints for follow-up scans were 23 days and 125 days, yielding accuracy/specificity/sensitivity 0.82/1.0/0.55 in identifying progressing lesions (p < 0.01).

Conclusion: BM typically exhibit an early volume increase with diffusion restriction after LITT. Responders then show bi-exponential shrinkage with gradual diffusion increase. Progression can usually be detected only after 3-4 months, because earlier radiographic patterns may overlap with responding lesions.

Key points: Question Laser interstitial thermal therapy (LITT) is an emerging local treatment for brain metastases, but the radiographic patterns following this treatment have not been thoroughly described. Findings Responding lesions showed a typical radiographic pattern with early volumetric enlargement and diffusion restriction (not exclusive of responders), followed by a bi-exponential shrinkage and diffusion elevation. Clinical relevance Being aware of the typical radiographic changes in brain metastases responding to LITT is informative for the interpretation of follow-up images. Early volumetric and diffusion changes (< 3-4 months) do not appear to be reliable markers to predict treatment success.