Jumping translocation of 3q in a patient with Mantle Cell Lymphoma: A case report and review of the literature.

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Cytogenetic and Genome Research Pub Date : 2025-05-08 DOI:10.1159/000546297

Elisavet Kouvidi, Georgios Boutsikas, Theofanis Giannikos, Marina Kalomoiraki, Ioanna Haralampous, Dimitra Boulari, Maria Dandoulaki, Maria Roumelioti, Paschalina Pallaki, Ioannis Anagnostopoulos

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引用次数: 0

Abstract

Introduction: Jumping translocations are rare cytogenetic events in hematologic malignancies, involving nonreciprocal translocation of a donor chromosome onto two or more recipient chromosomes.

Case presentation: In this paper, we report the first-ever case of a jumping translocation involving the long arm of chromosome 3 in a patient with Mantle Cell Lymphoma. The basic clone had the translocation t(11;14)(q13;q32) and a der(13)t(3;13)(q12;p11) and the three subclones had an additional jumping translocation, involving the translocation of 3q12 onto recipient chromosomes 14p, 15p and der(14)t(11;14), thus resulting in partial trisomy and tetrasomy 3q.

Conclusion: Although the underlying mechanism for the formation of jumping translocations is not well understood, their presence is usually associated with poor prognosis and clonal evolution and additional data are needed for their better clinical management.

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套细胞淋巴瘤患者3q跳位1例报告及文献复习。

跳跃易位是血液学恶性肿瘤中罕见的细胞遗传学事件，涉及供体染色体到两个或多个受体染色体的非互易易位。病例介绍：在本文中，我们报告了首例涉及3号染色体长臂的跳跃易位病例，患者为套细胞淋巴瘤。基本克隆发生了t(11;14)（q13;q32）和der(13)t(3;13)（q12;p11）易位，三个亚克隆发生了额外的跳跃易位，包括3q12易位到受体染色体14p、15p和der(14)t（11;14）上，从而形成部分三体和3q四体。结论：虽然跳跃易位形成的潜在机制尚不清楚，但它们的存在通常与预后不良和克隆进化有关，需要更多的数据来更好地进行临床管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytogenetic and Genome Research 生物-细胞生物学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.