The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms.

IF 2.9 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Alessandro Di Lisi, Asia Dalla Valle, Marco Menchetti, Concetta Crisafulli, Chiara Fabbri
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Abstract

Background: The conception of psychiatric disorders as systemic diseases implies an important role of nutrition in mental health. Essential trace elements are present in very small amounts in the body, yet they are essential for many physiological functions.

Methods: Little is known about the potential role of chromium and selenium supplementation in mental disorders and other populations. To contribute to filling this gap, this review is focused on the possible benefits of chromium and selenium, alone or in combination with pharmacological treatments, in the treatment of mental disorders or psychiatric symptoms.

Results: Chromium and selenium show promising effects on psychiatric symptoms across mental disorders. Selenium may have benefits on anxious-depressive symptoms in healthy populations and groups at risk of nutritional deficits and psychiatric symptoms, for example, women in the post-partum. In addition, chromium was linked to improved insulin sensitivity and glucose metabolism, which can benefit not only metabolic health but also mood regulation, with specific benefits on atypical symptoms of depression, such as appetite/weight gain. Selenium plays a role in reducing oxidative stress and inflammation, which may suggest positive effects on psychopathology and other conditions linked to these mechanisms.

Conclusions: Both trace elements may affect positively mental health and cardio-metabolic-inflammatory conditions, which have a strong link with psychiatric disorders and their prognosis. Despite the evidence is not conclusive, chromium and selenium supplementation are interesting options to investigate in future research on the personalization of treatment in mental disorders.

补充铬和硒对精神疾病和症状的潜在益处。
背景:精神疾病作为全身性疾病的概念意味着营养在精神健康中的重要作用。人体必需的微量元素含量极低,但它们对许多生理功能至关重要。方法:对铬和硒补充剂在精神障碍和其他人群中的潜在作用知之甚少。为了填补这一空白,本综述的重点是铬和硒单独或联合药物治疗在治疗精神障碍或精神症状方面的可能益处。结果:铬和硒对精神障碍患者的精神症状有良好的治疗效果。硒可能对健康人群和有营养缺乏和精神症状风险的群体(例如,产后妇女)的焦虑抑郁症状有好处。此外,铬与改善胰岛素敏感性和葡萄糖代谢有关,这不仅有利于代谢健康,还有利于情绪调节,对食欲/体重增加等非典型抑郁症症状有特殊益处。硒在减少氧化应激和炎症方面发挥作用,这可能表明对精神病理和其他与这些机制相关的疾病有积极作用。结论:这两种微量元素都可能对心理健康和心脏代谢炎症状况产生积极影响,这与精神疾病及其预后有很强的联系。尽管证据还不是结论性的,但铬和硒的补充是未来精神障碍个性化治疗研究的有趣选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
3.40%
发文量
231
审稿时长
4-8 weeks
期刊介绍: Journal of Clinical Psychopharmacology, a leading publication in psychopharmacology, offers a wide range of articles reporting on clinical trials and studies, side effects, drug interactions, overdose management, pharmacogenetics, pharmacokinetics, and psychiatric effects of non-psychiatric drugs. The journal keeps clinician-scientists and trainees up-to-date on the latest clinical developments in psychopharmacologic agents, presenting the extensive coverage needed to keep up with every development in this fast-growing field.
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