The lipid-heart hypothesis from the Seven Countries Study of Cardiovascular Diseases.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in lipidology Pub Date : 2025-04-23 DOI:10.1097/MOL.0000000000000993

Alessandro Menotti, Paolo Emilio Puddu

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Abstract

Purpose of review: To summarize and comment recent analyses from the Seven Countries Study of Cardiovascular Diseases (SCS) on the role of Atherogenicity (ATI) and Thrombogenicity (THI) indexes (created by combining several types of dietary fatty acids) in predicting major cardiovascular disease (CVD) and mainly coronary heart disease (CHD) mortalities in a long follow-up observation of ecological procedures involving 16 cohorts of middle-aged men.

Recent findings: In a chain of steps, a dietary score [Mediterranean Adequacy Index (MAI)] was inversely correlated with the ATI (R = -0.91). ATI directly correlated with serum cholesterol (R = +0.73) and serum cholesterol directly correlated with 50-year CHD mortality (R = +0.78). Moreover, MAI was inversely correlated (R = -0.91) and ATI was directly correlated with CHD mortality (R = +0.93). THI produced comparable results. In 10 cohorts reaching the extinction after 60 years of follow-up, results were similar. The same dietary and metabolic indicators were instead unrelated to other major types of CVD fatalities (heart diseases of uncertain etiology and stroke) or even inverse.

Summary: ATI and THI indices assembled by pooling several types of dietary fatty acids are strongly associated with long-term CHD mortality but not with other major CVD types.

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七国心血管疾病研究中的脂质-心脏假说。

综述目的：总结和评论七国心血管疾病研究（SCS）关于动脉粥样硬化性（ATI）和血栓形成性（THI）指数（由几种膳食脂肪酸组合而成）在预测主要心血管疾病（CVD）和主要冠心病（CHD）死亡率中的作用的最新分析，该研究涉及16个中年男性队列的生态程序长期随访观察。最近的研究发现：在一系列步骤中，饮食评分[地中海充足性指数（MAI）]与ATI呈负相关（R = -0.91）。ATI与血清胆固醇直接相关（R = +0.73），血清胆固醇与50年冠心病死亡率直接相关（R = +0.78）。MAI与冠心病死亡率呈负相关（R = -0.91）， ATI与冠心病死亡率呈正相关（R = +0.93）。THI产生了类似的结果。在随访60年后达到灭绝的10个队列中，结果相似。同样的饮食和代谢指标与其他主要类型的CVD死亡（病因不确定的心脏病和中风）无关，甚至相反。总结：ATI和THI指数与长期冠心病死亡率密切相关，但与其他主要心血管疾病类型无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.