Renal Resistive Index and 10-Year Risk of Cardiovascular Disease Predicted by Framingham Risk Score and Pooled Cohort Equations: An Observational Study in Hypertensive Individuals Without Cardiovascular Disease.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI:10.1007/s40292-025-00714-z

Giulio Geraci, Alessandra Sorce, Luca Zanoli, Vincenzo Calabrese, Giuseppe Cuttone, Alessandro Mattina, Pietro Ferrara, Ligia J Dominguez, Riccardo Polosa, Giuseppe Mulè, Caterina Carollo

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引用次数: 0

Abstract

Introduction: The renal resistive index (RRI) has been widely shown to be related with subclinical vascular damage in individuals with essential hypertension, as well as in other populations. However, limited data exist regarding the association between RRI and cardiovascular (CV) events in hypertensive individuals. Additionally, it is unclear whether the 10-year risk of CV disease, as predicted by validated score equations, is associated with impaired intrarenal hemodynamics.

Aim: The aim of our study was to analyze the relationship between RRI and both the FS and ASCVD in hypertensive individuals with no history of CV events.

Methods: A total of 742 individuals with essential hypertension (40-75 years) were enrolled. RRI was assessed in all patients using Duplex-Doppler ultrasonography, and the 10-year risk of cardiovascular disease was calculated using both the Framingham risk score (FS) and atherosclerotic cardiovascular disease risk score (ASCVD) through validated equations.

Results: Higher RRI values were observed in patients with calculated CV risk ≥ 20% compared to those with lower risk (all p < 0.001). RRI was closely associated with both FS and ASCVD scores in the overall cohort (all p < 0.001), with no significantly differences between groups with glomerular filtration rate ≥ or < 60 mL/min/1.73m². In multivariate analyses, these associations remained significant after adjusting for traditional risk factors included in the FS and ASCVD equations (p = 0.007 and p = 0.047, respectively). Receiver-operating characteristic curves indicated that RRI values >0.67 and >0.65 were associated with a high CV risk (≥ 20%), as calculated through FS and ASCVD equations, respectively.

Conclusion: RRI can be considered a marker of overall CV risk in hypertensive patients, independent of renal function.

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弗雷明汉风险评分和合并队列方程预测肾抵抗指数和10年心血管疾病风险：一项对无心血管疾病的高血压患者的观察性研究

肾阻力指数（RRI）已被广泛证明与原发性高血压患者以及其他人群的亚临床血管损伤有关。然而，关于高血压患者RRI与心血管（CV）事件之间关系的数据有限。此外，目前尚不清楚通过验证的评分方程预测的10年心血管疾病风险是否与肾内血流动力学受损有关。目的：本研究的目的是分析无心血管事件史的高血压患者RRI与FS和ASCVD的关系。方法：共纳入742例原发性高血压患者（40-75岁）。使用双多普勒超声评估所有患者的RRI，并通过验证方程使用Framingham风险评分（FS）和动脉粥样硬化性心血管疾病风险评分（ASCVD）计算10年心血管疾病风险。结果：计算CV风险≥20%的患者的RRI值高于风险较低的患者（p < 0.05）。在多变量分析中，在调整了FS和ASCVD方程中包含的传统危险因素后，这些相关性仍然显著（p = 0.007和p = 0.047）。受试者工作特征曲线显示，分别通过FS和ASCVD方程计算，RRI值>0.67和>0.65与高CV风险（≥20%）相关。结论：RRI可以被认为是高血压患者整体心血管风险的一个标志，独立于肾功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.