Optimal Window Settings for Detection and Characterization of Ground-Glass Opacities on Computed Tomography in COVID-19 Patients Using a Simplex Algorithm-Based Approach.

IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal Pub Date : 2025-05-01
Marron Daud, S Nahum Goldberg, Dotan Cohen, Gili Dar, Shiran Levy, Adam Nevo, Jacob Sosna, Naama Lev-Cohain
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引用次数: 0

Abstract

Background: Coronavirus disease-2019 (COVID-19) chest computed tomography (CT) involves ground-glass opacity (GGO) and denser consolidations, which are crucial for diagnosis.

Objectives: To determine optimal window settings for characterization and detection of GGO and dense consolidation on CT imaging in COVID-19 patients using a Simplex-based approach.

Methods: The study included 54 conventional CTs of COVID patients in two phases. First, CT images of 14 patients with GGO and 4 with dense consolidation were included. Seven radiologists evaluated representative images in different windows of varied width and center. They were graded for adequacy of characterization and detection. A Simplex algorithm was used to iteratively determine the optimal window settings. Surface response maps expressing the relationship between window settings and overall reader grades were constructed. Next, the reviewers compared manufacturer recommendations to the new optimal windows found on CT images of 40 patients.

Results: Overall, 12 different window settings were evaluated over a total of 1176 reads. Optimal characterization and detection of pure GGO was seen with a center of 630 HU and width 1460 HU, producing higher grades for both detection and characterization than the manufacturer window settings (P = 0.005). Optimal windowing for dense consolidation was like manufacturer measures (-585 HU and 1800 HU). In phase 2, an overwhelming preference of 78% favoring the optimal window compared to conventional settings was found.

Conclusions: GGO lung opacities characteristic for COVID-19 can be best seen using a lower CT windowing width than the manufacturer's recommendations, unlike denser consolidations, possibly due to differences in underlying pathophysiology.

基于单纯形算法的COVID-19患者计算机断层扫描毛玻璃混浊检测和表征的最佳窗口设置
背景:冠状病毒病-2019 (COVID-19)胸部计算机断层扫描(CT)包括磨玻璃影(GGO)和致密实变,这对诊断至关重要。目的:利用基于simplex的方法确定COVID-19患者CT成像表征和检测GGO和致密实变的最佳窗口设置。方法:对54例新冠肺炎患者进行两期常规ct检查。首先,纳入14例GGO患者和4例致密实变患者的CT图像。7位放射科医生在不同宽度和中心的不同窗口中评估代表性图像。它们根据特征和检测的充分性进行分级。采用单纯形算法迭代确定最佳窗口设置。构建了表达窗口设置与读者总体等级之间关系的表面响应图。接下来,评论者将制造商的建议与在40名患者的CT图像上发现的新的最佳窗口进行比较。结果:总体而言,在总共1176次读取中评估了12种不同的窗口设置。纯GGO的最佳表征和检测中心为630 HU,宽度为1460 HU,检测和表征的等级高于制造商窗口设置(P = 0.005)。密集固结的最佳窗口类似于制造商的措施(-585 HU和1800 HU)。在第二阶段,与传统设置相比,78%的人倾向于选择最佳窗口。结论:与致密实变不同,与制造商推荐的CT窗宽相比,使用较低的CT窗宽可以最好地看到COVID-19特征的GGO肺混浊,这可能是由于潜在病理生理的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Israel Medical Association Journal
Israel Medical Association Journal 医学-医学:内科
CiteScore
2.20
自引率
12.50%
发文量
54
审稿时长
3-8 weeks
期刊介绍: The Israel Medical Association Journal (IMAJ), representing medical sciences and medicine in Israel, is published in English by the Israel Medical Association. The Israel Medical Association Journal (IMAJ) was initiated in 1999.
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