Bioabsorbable Poly(vinyl alcohol)-Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model.

IF 1 Q4 CRITICAL CARE MEDICINE

European burn journal Pub Date : 2025-04-08 DOI:10.3390/ebj6020018

Jonalba Mendes Pereira, Emilia Angela Lo Schiavo Arisawa, Antônio Luiz Martins Maia Filho, José Figueredo-Silva, Nicoly Alves, Carolina Hahn da Silveira, Lucia Vieira

{"title":"Bioabsorbable Poly(vinyl alcohol)-Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model.","authors":"Jonalba Mendes Pereira, Emilia Angela Lo Schiavo Arisawa, Antônio Luiz Martins Maia Filho, José Figueredo-Silva, Nicoly Alves, Carolina Hahn da Silveira, Lucia Vieira","doi":"10.3390/ebj6020018","DOIUrl":null,"url":null,"abstract":"Background: The wound healing process presents notable challenges for nursing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combination promotes crosslinking, increases the dressing capacity of absorption and confers heal-ing properties due to the citric acid antioxidant action.Methods: The dressing was tested in a quantitative experiment on 1.9 cm acute dermatological lesions in rats (n = 12), com-paring the PVA-CA-treated group with the untreated control group (CG). Samples were collected at 3, 7 and 14 days after lesion induction to evaluate the inflammatory process and tissue healing.Results: The macroscopic and histological data on the third day showed similar characteristics in both groups; however, after fourteen days, the PVA-CA group exhibited complete healing, accompanied by recomposition of the skin layers, whereas the wounds in the CG did not close completely.Conclusions: The results highlight that electrospun PVA-AC dressings improve healing outcomes and constitute a prom-ising and affordable solution, providing a suitable environment for tissue repair, re-ducing inflammatory cell infiltration, blood vessel formation, and restoration of epi-thelial tissue, reducing the time of the healing process of acute wounds.","PeriodicalId":72961,"journal":{"name":"European burn journal","volume":"6 2","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015917/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European burn journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ebj6020018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The wound healing process presents notable challenges for nursing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combination promotes crosslinking, increases the dressing capacity of absorption and confers heal-ing properties due to the citric acid antioxidant action.

Methods: The dressing was tested in a quantitative experiment on 1.9 cm acute dermatological lesions in rats (n = 12), com-paring the PVA-CA-treated group with the untreated control group (CG). Samples were collected at 3, 7 and 14 days after lesion induction to evaluate the inflammatory process and tissue healing.

Results: The macroscopic and histological data on the third day showed similar characteristics in both groups; however, after fourteen days, the PVA-CA group exhibited complete healing, accompanied by recomposition of the skin layers, whereas the wounds in the CG did not close completely.

Conclusions: The results highlight that electrospun PVA-AC dressings improve healing outcomes and constitute a prom-ising and affordable solution, providing a suitable environment for tissue repair, re-ducing inflammatory cell infiltration, blood vessel formation, and restoration of epi-thelial tissue, reducing the time of the healing process of acute wounds.

查看原文本刊更多论文

生物可吸收聚乙烯醇-柠檬酸敷料：在实验体内模型中的伤口愈合研究。

背景：伤口愈合过程对护理团队提出了显著的挑战，需要广泛的伤口护理材料知识。研究了一种无纳米颗粒、生物可吸收的聚乙烯醇（PVA）和柠檬酸（CA）敷料在大鼠急性伤口愈合中的作用。这种PVA-CA的组合促进交联，增加敷料的吸收能力，并赋予愈合性能由于柠檬酸的抗氧化作用。方法：对大鼠1.9 cm急性皮肤病损伤（n = 12）进行定量实验，将pva - ca处理组与未处理对照组（CG）进行比较。在病变诱导后3、7和14天采集样本，评估炎症过程和组织愈合情况。结果：两组大鼠术后第3天的宏观和组织学资料具有相似特征；然而，14天后，PVA-CA组表现出完全愈合，并伴有皮肤层的重组，而CG中的伤口并未完全闭合。结论：电纺PVA-AC敷料改善了急性创面的愈合效果，为组织修复提供了合适的环境，减少了炎症细胞的浸润、血管的形成和上皮组织的修复，缩短了急性创面愈合过程的时间，是一种有前景且价格合理的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European burn journal

自引率

0.00%

发文量