Bioabsorbable Poly(vinyl alcohol)-Citric Acid Dressings: Wound Healing Studies in an Experimental In Vivo Model.

IF 1 Q4 CRITICAL CARE MEDICINE
Jonalba Mendes Pereira, Emilia Angela Lo Schiavo Arisawa, Antônio Luiz Martins Maia Filho, José Figueredo-Silva, Nicoly Alves, Carolina Hahn da Silveira, Lucia Vieira
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Abstract

Background: The wound healing process presents notable challenges for nursing teams, requiring extensive knowledge of wound care materials. A nanoparticle-free, bioabsorbable pol-yvinyl alcohol (PVA) with citric acid (CA) dressing produced by simple electrospin-ning was evaluated to treat acute wound healing in rats. This PVA-CA combination promotes crosslinking, increases the dressing capacity of absorption and confers heal-ing properties due to the citric acid antioxidant action.

Methods: The dressing was tested in a quantitative experiment on 1.9 cm acute dermatological lesions in rats (n = 12), com-paring the PVA-CA-treated group with the untreated control group (CG). Samples were collected at 3, 7 and 14 days after lesion induction to evaluate the inflammatory process and tissue healing.

Results: The macroscopic and histological data on the third day showed similar characteristics in both groups; however, after fourteen days, the PVA-CA group exhibited complete healing, accompanied by recomposition of the skin layers, whereas the wounds in the CG did not close completely.

Conclusions: The results highlight that electrospun PVA-AC dressings improve healing outcomes and constitute a prom-ising and affordable solution, providing a suitable environment for tissue repair, re-ducing inflammatory cell infiltration, blood vessel formation, and restoration of epi-thelial tissue, reducing the time of the healing process of acute wounds.

生物可吸收聚乙烯醇-柠檬酸敷料:在实验体内模型中的伤口愈合研究。
背景:伤口愈合过程对护理团队提出了显著的挑战,需要广泛的伤口护理材料知识。研究了一种无纳米颗粒、生物可吸收的聚乙烯醇(PVA)和柠檬酸(CA)敷料在大鼠急性伤口愈合中的作用。这种PVA-CA的组合促进交联,增加敷料的吸收能力,并赋予愈合性能由于柠檬酸的抗氧化作用。方法:对大鼠1.9 cm急性皮肤病损伤(n = 12)进行定量实验,将pva - ca处理组与未处理对照组(CG)进行比较。在病变诱导后3、7和14天采集样本,评估炎症过程和组织愈合情况。结果:两组大鼠术后第3天的宏观和组织学资料具有相似特征;然而,14天后,PVA-CA组表现出完全愈合,并伴有皮肤层的重组,而CG中的伤口并未完全闭合。结论:电纺PVA-AC敷料改善了急性创面的愈合效果,为组织修复提供了合适的环境,减少了炎症细胞的浸润、血管的形成和上皮组织的修复,缩短了急性创面愈合过程的时间,是一种有前景且价格合理的解决方案。
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