Use of atherogenic indices as predictors of cardiovascular risk in patients with irritable bowel síndrome.

Abstract

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder worldwide, with a higher prevalence between 8-31% in obese people. Obesity contributes to dyslipidemia.

Objective: This article aimed to compare the serum lipid profiles of patients with IBS and healthy controls (HC) to assess cardiovascular risk using different atherogenic indices.

Material and methods: Seventy-nine IBS patients and 45 HC were included in this study. Lipid profiles such as TGs, TC, HDL-C, LDL-C, VLDL-C, and atherogenic indices like atherogenic indices of plasma, Castelli risk indices I and II (CR-I and II), atherogenic coefficients (AC), and non-HDL-C were evaluated.

Results: Serum levels of HDL-C was lower in the IBS patients than in the HC (p < 0.0001). Serum levels of HDL-C were significantly lower in obese patients with IBS than in HC (p = 0.05). IBS patients had a greater risk of cardiovascular disease (CVD) than HC (CRI-I, p = 0.0301; CRI-II, p < 0.0001; and AC, p = 0.004).

Conclusions: Higher CRI-I, CRI-II, and AC scores were positively and strongly associated with IBS. These indices might be strong and independent predictors of CVD in IBS patients.