Multidimensional Prognostic Index as a Predictor of Mortality in Head and Neck Cancer Patients: A Cohort Study.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-05-06 DOI:10.1002/hed.28184

Ajay T Bakas, Aniel Sewnaik, Femke Flikweert, Robert Jan Baatenburg de Jong, Francesco Mattace-Raso, Harmke Polinder-Bos

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引用次数: 0

Abstract

Background: Head and neck cancer (HNC) significantly impacts older adults, with mortality influenced by multiple factors. The Multidimensional Prognostic Index (MPI), derived from comprehensive geriatric assessment (CGA), may improve risk stratification and clinical decision making.

Methods: An observational cohort study was conducted at Erasmus Medical Center, Rotterdam, from December 2019 to June 2021. We included 423 HNC patients aged 70 years or older or younger patients with a G8 score of 14 or less. MPI stages were determined through CGA, categorized into stages 1, 2, and 3.

Results: During a median follow-up of 595 days, 115 patients (29%) died. MPI stage 2 and stage 3 were associated with a higher mortality risk compared to MPI stage 1 (HR 2.18; 95% CI 1.46-3.26). In the surgical subgroup, similar mortality risks were observed, but MPI stages did not correlate with postoperative complications.

Conclusions: MPI stages derived from CGA effectively predict mortality risk in older HNC patients, though they do not predict postoperative complications.

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多维预后指数作为头颈癌患者死亡率的预测指标：一项队列研究。

背景：头颈癌（HNC）对老年人影响显著，其死亡率受多种因素影响。多维预后指数（MPI），源自综合老年评估（CGA），可以改善风险分层和临床决策。方法：2019年12月至2021年6月在鹿特丹伊拉斯谟医学中心进行了一项观察性队列研究。我们纳入了423例年龄≥70岁的HNC患者或G8评分≤14的年轻患者。通过CGA确定MPI分期，分为1期、2期和3期。结果：在中位595天的随访期间，115例患者（29%）死亡。与MPI 1期相比，MPI 2期和3期与更高的死亡风险相关(HR 2.18；95% ci 1.46-3.26)。在手术亚组中，观察到类似的死亡风险，但MPI分期与术后并发症无关。结论：CGA得出的MPI分期可有效预测老年HNC患者的死亡风险，但不能预测术后并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.