Analysis of serum levels of HIF-1α and IL-6 in patients with acute stanford type a aortic dissection.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2025-04-30 DOI:10.1186/s13019-025-03459-x

Zheyuan Wang, Junyi Wen, Shaoqin Chen, Lin Lu

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引用次数: 0

Abstract

Background: Studies have reported that Acute Stanford type A aortic dissection (ATAAD) is associated with hypoxia and inflammation. This study aims to explore the levels of HIF-1α and IL-6 in the serum of patients with ATAAD, and to analyze the association between these two factors as well as their potential clinical significance.

Methods: Serum samples were collected from 82 ATAAD patients and 19 healthy controls. Subsequently, the levels of HIF-1α and IL-6 in the serum of these samples were measured using the enzyme-linked immunosorbent assay (ELISA).

Results: The results showed that the serum HIF-1α level in patients with ATAAD were significantly reduced compared with the healthy control group [10.72 (7.28,14.92) vs. 19.54 ± 8.07 pg/mL, p < 0.0001], and the serum IL-6 level were significantly increased [3.12 (1.97, 9.13) vs. 1.13 (0.98, 1.42) pg/mL, p < 0.0001]. Moreover, there was no statistical difference of HIF-1α level in ATAAD patients with or without hypoxemia and IL-6. However, there was a significant positive correlation between the levels of IL-6 and the expression of HIF-1α (r = 0.5435, P < 0.0001).

Conclusion: We found that levels of HIF-1α and IL-6 were abnormal in patients with ATAAD. Moreover, the HIF-1α and IL-6 level in ATAAD patients were positively correlated, suggesting that HIF-1α and IL-6 may play roles simultaneously during the development of acute aortic dissection.

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急性stanford a型主动脉夹层患者血清HIF-1α和IL-6水平分析。

背景：已有研究报道急性Stanford A型主动脉夹层（ATAAD）与缺氧和炎症有关。本研究旨在探讨ATAAD患者血清中HIF-1α和IL-6的水平，并分析两者之间的相关性及其潜在的临床意义。方法：收集82例ATAAD患者和19例健康对照者的血清样本。随后，采用酶联免疫吸附试验（ELISA）测定这些样品血清中HIF-1α和IL-6的水平。结果：与健康对照组相比，ATAAD患者血清HIF-1α水平明显降低[10.72（7.28,14.92）比19.54±8.07 pg/mL, p]。结论：我们发现ATAAD患者血清HIF-1α和IL-6水平异常。此外，ATAAD患者HIF-1α和IL-6水平呈正相关，提示HIF-1α和IL-6可能在急性主动脉夹层的发生发展过程中同时发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.