Lei Li, Xiao-Feng Liu, Zhi-Fang Cui, Heng Zou, Shu-Ling Liu, Hong-Wu Wang
{"title":"The Mechanism of Traditional Chinese Medicine and Natural Medicine in Treating Chronic Obstructive Pulmonary Disease.","authors":"Lei Li, Xiao-Feng Liu, Zhi-Fang Cui, Heng Zou, Shu-Ling Liu, Hong-Wu Wang","doi":"10.2147/COPD.S518248","DOIUrl":null,"url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Chronic obstructive pulmonary disease (COPD) is one of the crucial chronic diseases that seriously endangers the health of residents in China. There is a complex mechanism of the pathogenesis of COPD, and no specific drugs are currently available to reverse the progressive decline in lung function during the natural course of COPD. Traditional Chinese Medicine (TCM) not only alleviates clinical symptoms, but also leads to fewer adverse reactions. However, the mechanism of action of TCM in COPD treatment remains unclear.</p><p><strong>Aim: </strong>To summarize the mechanisms of action of Chinese herbal compounds and natural drugs in the treatment of COPD and identify potential signaling pathways and targets that can provide preclinical evidence for the treatment of COPD.</p><p><strong>Methods: </strong>Literature was retrieved from the scientific databases PubMed, Web of Science, and CNKI, Wanfang Data Knowledge Service Platform, and VIP Chinese Science and Technology Journal from July 2007 to December 2023.</p><p><strong>Results: </strong>This study introduced the specific pathways, targets and mechanisms of TCM in treating COPD from the perspectives of inhibiting inflammation, reducing oxidative stress, and regulating autophagy.</p><p><strong>Conclusion: </strong>This study provides a comprehensive summary of the theories of Chinese medicine in treating COPD, which utilize multiple targets and pathways to display the advantages of Chinese medicine. This lays the foundation for further exploration of pathways related to Chinese medicine for the treatment of COPD.</p>","PeriodicalId":48818,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":"20 ","pages":"1249-1266"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042842/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chronic Obstructive Pulmonary Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/COPD.S518248","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Ethnopharmacological relevance: Chronic obstructive pulmonary disease (COPD) is one of the crucial chronic diseases that seriously endangers the health of residents in China. There is a complex mechanism of the pathogenesis of COPD, and no specific drugs are currently available to reverse the progressive decline in lung function during the natural course of COPD. Traditional Chinese Medicine (TCM) not only alleviates clinical symptoms, but also leads to fewer adverse reactions. However, the mechanism of action of TCM in COPD treatment remains unclear.
Aim: To summarize the mechanisms of action of Chinese herbal compounds and natural drugs in the treatment of COPD and identify potential signaling pathways and targets that can provide preclinical evidence for the treatment of COPD.
Methods: Literature was retrieved from the scientific databases PubMed, Web of Science, and CNKI, Wanfang Data Knowledge Service Platform, and VIP Chinese Science and Technology Journal from July 2007 to December 2023.
Results: This study introduced the specific pathways, targets and mechanisms of TCM in treating COPD from the perspectives of inhibiting inflammation, reducing oxidative stress, and regulating autophagy.
Conclusion: This study provides a comprehensive summary of the theories of Chinese medicine in treating COPD, which utilize multiple targets and pathways to display the advantages of Chinese medicine. This lays the foundation for further exploration of pathways related to Chinese medicine for the treatment of COPD.
民族药理学相关性：慢性阻塞性肺疾病（COPD）是严重危害中国居民健康的重要慢性疾病之一。COPD的发病机制复杂，目前尚无特异性药物能够逆转COPD自然病程中肺功能的进行性下降。中药不仅能缓解临床症状，还能减少不良反应。然而，中药在COPD治疗中的作用机制尚不清楚。目的：总结中药复方和天然药物治疗慢性阻塞性肺病的作用机制，发现潜在的信号通路和靶点，为慢性阻塞性肺病的治疗提供临床前证据。方法：检索PubMed、Web of Science、中国知网（CNKI）、万方数据知识服务平台、维普中国科技期刊（VIP Chinese Science and Technology Journal） 2007年7月- 2023年12月的文献。结果：本研究从抑制炎症、降低氧化应激、调节自噬等方面介绍了中医药治疗COPD的具体途径、靶点和机制。结论：本研究全面总结了中医药治疗慢性阻塞性肺病的理论，利用多靶点、多途径发挥中医药的优势。这为进一步探索中医治疗COPD的相关途径奠定了基础。
期刊介绍：
An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
