Electrophilic (Hetero)Arene C-H Nitration by Ferric Nitrate Nonahydrate in Hexafluoroisopropanol.

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-15 DOI:10.1021/acs.joc.5c00137

Yuzhu Zheng,Zongyi Liu,Zhaobo Ying,Youwei Xie

引用次数: 0

Abstract

In this article, we provide an extended substrate scope and more detailed mechanistic studies of an operationally simple and generally applicable arene nitration that we previously reported. This method utilizes safe and inexpensive Fe(NO3)3•9H2O as the nitro source in easily recyclable HFIP and obviates the need for corrosive acids (HNO3 + H2SO4). As a result, we speculated that it could serve as an effective substitute for the traditional mixed acid approach under most scenarios due to its operational simplicity. A general guidance for the application of this method was provided.

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非水合硝酸铁在六氟异丙醇中硝化亲电（杂）芳烃的研究。

在这篇文章中，我们提供了一个扩展的底物范围和更详细的机理研究，操作简单，普遍适用的芳烃硝化，我们之前的报道。该方法利用安全且廉价的Fe(NO3)3•9H2O作为易于回收的HFIP中的硝基源，并且避免了对腐蚀性酸（HNO3 + H2SO4）的需要。因此，我们推测，由于其操作简单，在大多数情况下可以作为传统混合酸方法的有效替代品。为该方法的应用提供了一般指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.