Correlation of AMH Levels with Clinical, Biochemical and Hormonal Parameters Among Infertile Women with PCOS.

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a multisystem endocrinopathy with a varied clinical presentation; there are very few studies about relationship of anti-Mullerian hormone (AMH) levels with different clinical, biochemical and hormonal parameters of PCOS. It is still uncertain whether an increase in AMH levels has a positive correlation with hyperandrogenism or with oligoanovulation. This study aims to establish a correlation of AMH levels with clinical, biochemical and hormonal parameters among infertile women with PCOS.

Method: An observational cross-sectional study was conducted at Lady Hardinge Medical College and Hospital, Delhi, during the period November 2018 to March 2020. A total of 143 infertile women between 20 and 35 years of age diagnosed to have PCOS based on the revised Rotterdam diagnostic criteria were recruited. After brief history and examination, blood samples were taken for AMH and other biochemical and hormonal tests. Transvaginal ultrasound was performed to see the ovarian volume, antral follicles and endometrial thickness.

Results: There was a weak positive statistically significant (r = 0.17, p = 0.047) correlation between cycle length and AMH. A weak negative correlation between sex hormone binging globulin (SHBG) and AMH was found, and this correlation was statistically significant (p = 0.007).

Conclusion: Serum AMH is correlated positively with oligoanovulation and negatively with levels of SHBG which suggests an indirect positive correlation of AMH with hyperandrogenism as SHBG is low in women with hyperandrogenism.