A case of phosphoglyceride crystal deposition disease in the maxilla.

IF 2.4 3区 医学 Q2 PATHOLOGY
Emi Saitou, Takaaki Sano, Mai Seki, Takahiro Yamaguchi, Tetsunari Oyama, Satoshi Yokoo
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引用次数: 0

Abstract

Background: Phosphoglyceride crystal deposition disease (PCDD) is a rare disorder in which phosphoglyceride crystals accumulate in soft tissues and bones. It tends to occur years after surgery, trauma, or repeated injections.

Case presentation: An 81-year-old woman was referred to our department because of swelling of the left maxillary gingiva. The left maxillary second molar had been extracted more than 10 years earlier. Surgical biopsy was performed, and histopathological findings indicated a foreign body granuloma. The patient underwent tumorectomy, during which we found a yellowish tumor. The pathologic findings were the characteristic crystal deposition, fibril-like crystals, and giant cells around the crystals. Gold hydroxamic acid staining revealed positivity for the crystals. The final pathological diagnosis was PCDD. The patient had no further symptoms and no disease recurrence.

Conclusions: It is relatively easy to diagnose PCDD from the characteristic histopathological findings; however, it may be overlooked by pathologists who are unaware of the disease. T2-weighted magnetic resonance imaging of PCDD in the jawbone has depicted low intensity, a finding that differs from those of ordinary cancers and odontogenic tumors. The oral cavity often undergoes surgical procedures, and PCDD may form, and grow.

上颌骨甘油三酯晶体沉积病1例。
背景:磷酸甘油酯晶体沉积病(PCDD)是一种罕见的疾病,其中磷酸甘油酯晶体积聚在软组织和骨骼。它往往发生在手术、创伤或反复注射多年后。病例介绍:一名81岁妇女因左上颌牙龈肿胀而转介至我科。左上颌第二磨牙早于10多年前拔除。手术活检,组织病理学结果显示异物肉芽肿。病人接受了肿瘤切除术,手术中我们发现了一个淡黄色的肿瘤。病理表现为特征性晶体沉积,纤维样晶体,晶体周围有巨细胞。金羟基肟酸染色显示晶体阳性。最终病理诊断为PCDD。患者无进一步症状,无疾病复发。结论:PCDD的特征性病理表现相对容易诊断;然而,它可能被不了解疾病的病理学家所忽视。颌骨PCDD的t2加权磁共振成像显示低强度,这一发现不同于普通癌症和牙源性肿瘤。口腔经常经历外科手术,PCDD可能形成并生长。
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来源期刊
Diagnostic Pathology
Diagnostic Pathology 医学-病理学
CiteScore
4.60
自引率
0.00%
发文量
93
审稿时长
1 months
期刊介绍: Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).
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