Tailoring CdO-CuO-ZnO Mixed Metal Oxide Nanocomposites for Anticancer Activity via Co-Precipitation Method.

IF 4.9 Q2 NANOSCIENCE & NANOTECHNOLOGY

Nanotechnology, Science and Applications Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI:10.2147/NSA.S519229

Shadha Nasser Aziz, Abduh Mohammad Abdulwahab, Thana Shuga Aldeen, Abdullah Ahmed Ali Ahmed

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引用次数: 0

Abstract

Introduction: The use of metal oxide nanoparticles as anticancer agents is of great interest due to their unique properties that allow targeted delivery at low concentrations with minimal toxicity to healthy cells.

Methods: In this work, CdO-CuO-ZnO mixed metal oxide nanocomposites were synthesized by the co-precipitation method, and their structural and optical properties, along with their anticancer activity, were investigated. The samples were characterized by X-ray diffraction (XRD), total reflection X-ray fluorescence (TXRF), transmission electron microscopy (TEM), selected area electron diffraction (SAED), UV-Vis spectroscopy, electrometer/high resistance material, and vibrating sample magnetometers (VSM).

Results: X-ray diffraction (XRD) measurements showed that CdO exhibits a cubic structure, CuO possesses a monoclinic structure, ZnO displays a hexagonal structure, and the mixture showed peaks corresponding to all three oxides. TEM images revealed that the prepared nanoparticles have quasi-spherical shapes. Anticancer studies confirmed that the CdO-CuO-ZnO nanocomposite demonstrates excellent cytotoxicity, with moderate activity against human colon (Caco-2) and lung (A549) cancer cell lines, exhibiting IC50 values of 10.57 μg/mL and 6.61 μg/mL, respectively.

Conclusion: Our study shows that the prepared CdO-CuO-ZnO nanocomposite has massive potential in cancer therapy.

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通过共沉淀法裁剪CdO-CuO-ZnO混合金属氧化物纳米复合材料的抗癌活性。

金属氧化物纳米颗粒作为抗癌药物的使用引起了人们的极大兴趣，因为它们具有独特的特性，可以在低浓度下靶向递送，对健康细胞的毒性最小。方法：采用共沉淀法合成了CdO-CuO-ZnO混合金属氧化物纳米复合材料，并对其结构、光学性质及抗癌活性进行了研究。采用x射线衍射（XRD）、x射线全反射荧光（TXRF）、透射电镜（TEM）、选择区域电子衍射（SAED）、紫外可见光谱（UV-Vis）、静电计/高阻材料、振动样品磁强计（VSM）对样品进行了表征。结果：x射线衍射（XRD）测试结果表明，CdO为立方结构，CuO为单斜结构，ZnO为六方结构，混合产物具有三种氧化物对应的峰。TEM图像显示制备的纳米颗粒具有准球形。抗癌研究证实，CdO-CuO-ZnO纳米复合材料具有良好的细胞毒性，对人结肠癌（Caco-2）和肺癌（A549）具有中等活性，IC50值分别为10.57 μg/mL和6.61 μg/mL。结论：所制备的氧化铜氧化锌纳米复合材料在癌症治疗中具有巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanotechnology, Science and Applications NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

11.70

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Nanotechnology, Science and Applications is an international, peer-reviewed, Open Access journal that focuses on the science of nanotechnology in a wide range of industrial and academic applications. The journal is characterized by the rapid reporting of reviews, original research, and application studies across all sectors, including engineering, optics, bio-medicine, cosmetics, textiles, resource sustainability and science. Applied research into nano-materials, particles, nano-structures and fabrication, diagnostics and analytics, drug delivery and toxicology constitute the primary direction of the journal.