N4BP1 as a modulator of the NF-κB pathway.

Abstract

NEDD4-binding protein 1 (N4BP1) is emerging as a critical regulator of inflammation and immune responses, particularly through its effects on the nuclear factor-κ-gene binding (NF-κB) signaling pathway. This review summarizes the regulatory mechanisms by which N4BP1 inhibits NF-κB activation and its subsequent impact on inflammatory diseases, specifically psoriasis. We discuss its interaction with various components of the NF-κB pathway, revealing that N4BP1 serves as a negative regulator of NF-κB-related gene expression under both stimulated and unstimulated conditions. Evidence highlights that N4BP1 is pivotal in controlling keratinocyte behavior and immune cell dynamics, thus influencing psoriasis pathology. Furthermore, we explore the emerging role of N4BP1 in viral infections, demonstrating its inhibitory effects on human immunodeficiency virus (HIV) replication. The involvement of N4BP1 in Notch signaling and neurogenesis underscores its multifaceted roles in cellular development and response to external stimuli. Collectively, these findings position N4BP1 as a significant player in modulating immune responses and offer potential therapeutic avenues for managing inflammatory diseases and viral infections.