Value of hypoplastic nasal bone at 11-14 weeks' gestation for the detection of fetal aneuploidy in a Mexican population.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI:10.24875/GMM.M24000960

Cervantes-Ricaud J Alfredo, Oviedo-Cruz Héctor

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引用次数: 0

Abstract

Background: The standardized assessment of the hypoplastic nasal bone (NB) by ultrasonography between 11-14 weeks' gestation has value in the detection of fetal aneuploidies. The frequency of hypoplastic NB varies between populations and is unknown in Mexico.

Objective: To analyze the performance of hypoplastic NB for the early detection of fetal aneuploidies in a Mexican population.

Material and methods: A nested case-control study in a cohort of Mexican pregnant women. The inclusion criteria were live fetus with crown-rump length (CRL) 45-84 mm and the result of perinatal karyotype or phenotype at birth. Ultrasonographic assessment of the NB was standardized. The statistical analyses were univariable, multiple logistic regression, Bayes' theorem and performance.

Results: A total of 65 cases and 1187 controls were studied, with maternal age of 1753 years. The frequency of hypoplastic NB was 1.6% (95% CI, 0.9-2.3) in euploid fetuses versus 44.6% (95% CI, 32.5-56.7) with aneuploidies (p < 0.001, X²). Sensitivity for trisomy 21 was 58.3% (PPV 52.5%, NPV 98.7%). The probability of the hypoplastic NB was conditioned by aneuploidy (type), CRL, and nuchal translucency. The C-statistic of the Bayesian model was 0.904 (95% CI, 0.842-0.965).

Conclusions: A Mexican model of the NB had added value in the early detection of fetal aneuploidies.

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墨西哥人群妊娠11-14周鼻骨发育不全对胎儿非整倍体检测的价值

背景：在妊娠11-14周期间用超声对发育不全鼻骨（NB）进行标准化评估对胎儿非整倍体的检测有价值。NB发育不良的频率因人群而异，在墨西哥尚不清楚。目的：分析发育不良NB在墨西哥人群胎儿非整倍体早期检测中的作用。材料和方法：在墨西哥孕妇队列中进行巢式病例对照研究。纳入标准为冠臀长（CRL） 45 ~ 84 mm的活胎和出生时围生期核型或表型结果。NB的超声评估标准化。统计分析采用单变量、多元逻辑回归、贝叶斯定理和性能分析。结果：本组共65例，对照组1187例，产妇年龄1753岁。整倍体胎儿发育不良发生率为1.6% (95% CI, 0.9-2.3)，非整倍体胎儿为44.6% (95% CI, 32.5-56.7) （p < 0.001, X2）。21三体的敏感性为58.3% （PPV为52.5%，NPV为98.7%）。NB发育不全的概率由非整倍体（类型）、CRL和颈部透明度决定。贝叶斯模型的c统计量为0.904 （95% CI, 0.842 ~ 0.965）。结论：墨西哥NB模型在胎儿非整倍体的早期检测中具有附加价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gaceta medica de Mexico 医学-医学：内科

CiteScore

1.00

自引率

0.00%

发文量

216

审稿时长

6-12 weeks

期刊介绍： Gaceta Médica de México México is the official scientific journal of the Academia Nacional de Medicina de México, A.C. Its goal is to contribute to health professionals by publishing the most relevant progress both in research and clinical practice. Gaceta Médica de México is a bimonthly peer reviewed journal, published both in paper and online in open access, both in Spanish and English. It has a brilliant editorial board formed by national and international experts.