Association of Serum Uric Acid Levels with Cardiometabolic Factors in Adolescents with Obesity: A Cross-Sectional Study.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-03-31 DOI:10.3390/metabo15040237

Miguel Angel Villasis-Keever, Jessie Nallely Zurita-Cruz, Iris Alejandra Alcaraz-Hurtado, Miguel Klünder-Klünder, Jenny Vilchis-Gil, Ana Laura Romero-Guerra, Ana Laura López-Beltran, Martha Alicia Delgadillo-Ruano

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引用次数: 0

Abstract

Introduction: High serum uric acid (SUA) levels are known to be correlated with cardiometabolic factors in adults, but this relationship is less clear in the pediatric population, particularly given the undefined cutoff points for high SUA levels.

Objetive: This study aimed to explore the associations between SUA levels and cardiometabolic factors in obese adolescents.

Materials and methods: We conducted a cross-sectional study of 391 adolescents aged 10 to 18 years with obesity (BMI > 95th percentile), assessing outcomes such as hypertriglyceridemia, reduced HDL cholesterol, hypertension, hyperglycemia, and insulin resistance. The statistical methods used to compare SUA levels with cardiometabolic factors included the Mann-Whitney U test and the chi-square test.

Results: The results revealed that the median SUA level was 5.9 mg/dL, with significant differences between the sexes (5.5 mg/dL for girls and 6.1 mg/dL for boys). The highest SUA tertile (≥6.41 mg/dL) was associated with a significantly greater frequency of hyperglycemia and hypertriglyceridemia than the lowest tertile (p < 0.005).

Conclusions: The study concluded that higher SUA levels are significantly associated with specific cardiometabolic risks in adolescents with obesity, highlighting the importance of monitoring SUA levels in this population.

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青少年肥胖患者血清尿酸水平与心脏代谢因子的相关性：一项横断面研究。

在成人中，高血清尿酸（SUA）水平已知与心脏代谢因子相关，但这种关系在儿科人群中不太清楚，特别是考虑到高SUA水平的未定义截止点。目的：探讨肥胖青少年SUA水平与心脏代谢因子的关系。材料和方法：我们对391名年龄在10至18岁的肥胖青少年（BMI为95百分位）进行了一项横断面研究，评估了高甘油三酯血症、高密度脂蛋白胆固醇降低、高血压、高血糖和胰岛素抵抗等结果。比较SUA水平与心脏代谢因素的统计方法包括Mann-Whitney U检验和卡方检验。结果：结果显示，中位SUA水平为5.9 mg/dL，性别差异显著（女孩为5.5 mg/dL，男孩为6.1 mg/dL）。最高SUA分位数（≥6.41 mg/dL）与高血糖和高甘油三酯血症的发生频率显著高于最低SUA分位数（p < 0.005）。结论：该研究得出结论，较高的SUA水平与肥胖青少年特定的心脏代谢风险显著相关，强调了监测这一人群中SUA水平的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.