Genomic Epidemiology for Estimating Pathogen Burden in a Population.

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-05-01 DOI:10.3201/eid3113.241203

W Tanner Porter, David M Engelthaler, Crystal M Hepp

引用次数: 0

Abstract

The role of genomics in outbreak response and pathogen surveillance has expanded and ushered in the age of pathogen intelligence. Genomic surveillance enables detection and monitoring of novel pathogens; case clusters; and markers of virulence, antimicrobial resistance, and immune escape. We can leverage pathogen genomic diversity to estimate total pathogen burden in populations and environments, which was previously challenging because of unreliable data. Pathogen genomics might allow pathogen burdens to be estimated by sequencing even a small percentage of cases. Deeper genomic epidemiology analyses require multidisciplinary collaboration to ensure accurate and actionable real-time pathogen intelligence.

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基因组流行病学用于估计人群中的病原体负担。

基因组学在疫情应对和病原体监测中的作用已经扩大，并迎来了病原体情报时代。基因组监测能够发现和监测新的病原体；集群;以及毒力、抗菌素耐药性和免疫逃逸的标记。我们可以利用病原体基因组多样性来估计人群和环境中的总病原体负担，这在以前是具有挑战性的，因为数据不可靠。病原体基因组学可以通过对一小部分病例进行测序来估计病原体负担。更深入的基因组流行病学分析需要多学科合作，以确保准确和可操作的实时病原体情报。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.