Mapping the ADDQoL to the EQ-5D-5L and SF-6Dv2 among Chinese patients with type 2 diabetes mellitus.

IF 3.2 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES
Haoran Fang, Tianqi Hong, Xinran Liu, Chang Luo, Yuanyuan Hou, Shitong Xie
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Abstract

Objective: The Audit of Diabetes-Dependent Quality of Life (ADDQoL) is a widely used instrument for assessing quality of life in Type 2 Diabetes Mellitus (T2DM). However, it does not directly yield health utility values essential for economic evaluations. This study developed mapping algorithms to predict EQ-5D-5L and SF-6Dv2 utility values from ADDQoL scores in T2DM patients in China.

Methods: Cross-sectional data from 800 T2DM patients in China, stratified by age, sex, and geographical region, were divided into development (80%) and validation (20%) groups. Pearson correlation analyses were conducted to assess the conceptual overlap between ADDQoL and the EQ-5D-5L and SF-6Dv2. Six predictor sets and six regression methods were explored to map ADDQoL scores to EQ-5D-5L and SF-6Dv2 utility values, respectively. Model performance was evaluated using mean absolute error (MAE), root mean square error (RMSE), and intraclass correlation coefficient (ICC).

Results: For the development group, the mean (SD) ADDQoL Average Weighted Impact (AWI) score was - 2.426 (1.052), and the mean (SD) utility values for EQ-5D-5L and SF-6Dv2 were 0.928 (0.092) and 0.791 (0.133), respectively. Among all 36 alternative mapping models each for EQ-5D-5L and SF-6Dv2, the best performance was consistently observed in the two-part models that included the ADDQoL AWI, the first overview item, and their squared terms. For the algorithm mapping to EQ-5D-5L utility values, it achieved a MAE of 0.067, a RMSE of 0.095, and an ICC of 0.414; For the algorithm mapping to SF-6Dv2 utility values, the corresponding metrics were an MAE of 0.099, an RMSE of 0.120, and an ICC of 0.517.

Conclusions: This study provides a mapping framework to estimate EQ-5D-5L and SF-6Dv2 utility values from ADDQoL scores. These algorithms could be used to support economic evaluations, specifically tailored for Chinese T2DM populations.

中国2型糖尿病患者的ADDQoL与EQ-5D-5L和SF-6Dv2的关系
目的:糖尿病依赖生活质量审计(ADDQoL)是一种广泛使用的评估2型糖尿病(T2DM)生活质量的工具。然而,它不能直接产生经济评价所必需的健康效用值。本研究开发了映射算法来预测中国T2DM患者的ADDQoL评分中EQ-5D-5L和SF-6Dv2的效用值。方法:来自中国800名T2DM患者的横断面数据,按年龄、性别和地理区域分层,分为发展组(80%)和验证组(20%)。采用Pearson相关分析评估ADDQoL与EQ-5D-5L和SF-6Dv2之间的概念重叠。研究了6个预测集和6种回归方法,分别将ADDQoL评分与EQ-5D-5L和SF-6Dv2效用值相关联。使用平均绝对误差(MAE)、均方根误差(RMSE)和类内相关系数(ICC)来评估模型的性能。结果:开发组ADDQoL平均加权影响(AWI)评分为- 2.426 (1.052),EQ-5D-5L和SF-6Dv2的平均效用值分别为0.928(0.092)和0.791(0.133)。在EQ-5D-5L和SF-6Dv2的所有36个备选映射模型中,包括ADDQoL AWI、第一个概述项及其平方项的两部分模型一致地观察到最佳性能。对于EQ-5D-5L效用值的算法映射,MAE为0.067,RMSE为0.095,ICC为0.414;对于映射到SF-6Dv2效用值的算法,相应的指标是MAE为0.099,RMSE为0.120,ICC为0.517。结论:本研究提供了一个从ADDQoL评分中估计EQ-5D-5L和SF-6Dv2效用值的映射框架。这些算法可用于支持经济评估,特别为中国T2DM人群量身定制。
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来源期刊
CiteScore
7.30
自引率
2.80%
发文量
154
审稿时长
3-8 weeks
期刊介绍: Health and Quality of Life Outcomes is an open access, peer-reviewed, journal offering high quality articles, rapid publication and wide diffusion in the public domain. Health and Quality of Life Outcomes considers original manuscripts on the Health-Related Quality of Life (HRQOL) assessment for evaluation of medical and psychosocial interventions. It also considers approaches and studies on psychometric properties of HRQOL and patient reported outcome measures, including cultural validation of instruments if they provide information about the impact of interventions. The journal publishes study protocols and reviews summarising the present state of knowledge concerning a particular aspect of HRQOL and patient reported outcome measures. Reviews should generally follow systematic review methodology. Comments on articles and letters to the editor are welcome.
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