The co-occurrence of spondylodiscitis and periprosthetic joint infections: clinical and microbiological perspectives.

IF 2 3区医学 Q2 ORTHOPEDICS

International Orthopaedics Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI:10.1007/s00264-025-06556-7

Mustafa Fatih Dasci, Jorge H Núñez, Özkan Köse, N Amir Sandiford, Berfin Selin Caliskan, Tianyi David Luo, Thorsten Gehrke, Mustafa Citak

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引用次数: 0

Abstract

Purpose: To assess the potential relationship between synchronous and metachronous occurrences of spondylodiscitis and subsequent periprosthetic joint infection (PJI), shedding light on the interplay between these two distinct yet interconnected conditions. The secondary aim was to investigate the time interval between the occurrences of spondylodiscitis and PJI in metachronous infections, and to identify potential similarities or differences in the causative pathogens between synchronous and metachronous infections.

Methods: A retrospective single-center study was performed. Patients diagnosed with either spondylodiscitis or PJI (based on the 2018 International Consensus Meeting criteria) were included. Demographic, clinical, laboratory and microbiology patient data were retrieved.

Results: The incidence of metachronous infection and synchronous infection were 86.7% and 13.3% respectively. In metachronous infections, time between spondylodiscitis and PJI was 29.1 months (SD 31.1). The most common relation between spondylodiscitis and PJI were between hip PJI and lumbar spondylodiscitis. There was a statistically significant difference in the time between spondylodiscitis and PJI in the patient who had or had not arthroplasty prior to the spondylodiscitis (p = 0.02). The spondylodiscitis and PJI concomitant infection were predominant a monobacterial infection. Staphylococcus aureus was the most frequent species isolated (47.6%). The same organism was isolated in the cultures in metachronous and in the synchronous infections between spondylodiscitis and PJI in 100% of cases.

Conclusion: The findings of this study suggest a potential link between spondylodiscitis and PJI; however, further research is required to understand the mechanisms underlying the potential relationship between these events, as well as to develop effective strategies for prevention, diagnosis, and treatment of these infections.

Level of evidence: Level IV, Retrospective case series.

查看原文本刊更多论文

脊柱椎间盘炎和假体周围关节感染的共同发生：临床和微生物学观点。

目的：评估同步和异时性脊柱椎间盘炎与随后的假体周围关节感染（PJI）之间的潜在关系，揭示这两种不同但相互关联的疾病之间的相互作用。次要目的是调查异时性感染中脊柱炎和PJI发生的时间间隔，并确定同步感染和异时性感染之间致病病原体的潜在相似性或差异性。方法：采用回顾性单中心研究。被诊断为脊柱炎或PJI的患者（基于2018年国际共识会议标准）被纳入。检索患者的人口学、临床、实验室和微生物学数据。结果：异时感染和同步感染的发生率分别为86.7%和13.3%。在异时性感染中，脊柱炎和PJI之间的时间为29.1个月（SD为31.1）。椎间盘炎与PJI之间最常见的关系是髋关节PJI与腰椎椎间盘炎之间的关系。在椎间盘炎前做过或没有做过关节置换术的患者中，椎间盘炎和PJI的时间差异有统计学意义（p = 0.02）。脊柱椎间盘炎和PJI合并感染以单细菌感染为主。分离出的金黄色葡萄球菌最多（47.6%）。在脊柱炎和PJI之间的异时性和同步感染的培养中，100%的病例分离到相同的生物。结论：本研究结果提示脊柱椎间盘炎与PJI之间存在潜在联系；然而，需要进一步的研究来了解这些事件之间潜在关系的机制，以及制定有效的预防、诊断和治疗这些感染的策略。证据等级：四级，回顾性病例系列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Orthopaedics 医学-整形外科

CiteScore

5.50

自引率

7.40%

发文量

360

审稿时长

1 months

期刊介绍： International Orthopaedics, the Official Journal of the Société Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT) , publishes original papers from all over the world. The articles deal with clinical orthopaedic surgery or basic research directly connected with orthopaedic surgery. International Orthopaedics will also link all the members of SICOT by means of an insert that will be concerned with SICOT matters. Finally, it is expected that news and information regarding all aspects of orthopaedic surgery, including meetings, panels, instructional courses, etc. will be brought to the attention of the readers. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted. Reports of animal experiments must state that the "Principles of laboratory animal care" (NIH publication No. 85-23, revised 1985) were followed, as well as specific national laws (e.g. the current version of the German Law on the Protection of Animals) where applicable. The editors reserve the right to reject manuscripts that do not comply with the above-mentioned requirements. The author will be held responsible for false statements or for failure to fulfil the above-mentioned requirements.