Combination of autophagy inhibitors with high-dose CDK4/6 inhibitors offers new hope for advanced HR+/HER2- breast cancer.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-05-09 DOI:10.1016/j.medj.2024.100571

Li-Ping Ge, Yi-Zhou Jiang

引用次数: 0

Abstract

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) with endocrine therapy are standard for advanced hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer. However, treatment options following resistance to CDK4/6is remain poorly defined. Gong et al. conducted a phase 1b/2 trial, demonstrating that autophagy inhibitors combined with high-dose CDK4/6is are well tolerated and effective in patients with advanced HR+/HER2- breast cancer resistant to first-line CDK4/6i therapy.¹.

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自噬抑制剂联合大剂量CDK4/6抑制剂为晚期HR+/HER2-乳腺癌提供了新的希望。

周期蛋白依赖性激酶4/6抑制剂（CDK4/6is）配合内分泌治疗是晚期激素受体阳性/HER2阴性（HR+/HER2-）乳腺癌的标准治疗方法。然而，cdk4 /6耐药后的治疗选择仍然不明确。Gong等进行的1b/2期试验表明，自噬抑制剂联合大剂量CDK4/6is对一线CDK4/6i治疗耐药的晚期HR+/HER2-乳腺癌患者具有良好的耐受性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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