Recreational drugs repurposed for medicinal use-cannabis.

IF 3.4 3区 医学 Q2 CLINICAL NEUROLOGY
Mike Armour, Justin Sinclair, Hannah Adler
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引用次数: 0

Abstract

Cannabis has a long history as a medicine and was a part of medical practice until the late 19th century. The discovery of cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) in the mid-20th century, and then the various components of the endocannabinoid system (ECS) over the following decades has again brought cannabis back into the public eye as a potential therapeutic agent. At present, cannabis is being used in the community across the world for both recreational and medical purposes. In the case of medical usage, it may be prescribed by a medical doctor or purchased either legally or illicitly for medical purposes such as symptom relief. Evidence for cannabis as a medicine is still an emerging field, and while potential mechanisms of action for a variety of conditions have been elucidated, including cancer, epilepsy, and chronic pain, high-quality randomized controlled trials in humans are still lacking. Despite popular beliefs, cannabis, like all other medicines, has potential benefits and harms, and long-term consumption of cannabis, even for medical reasons, may not be risk-free. In addition, consumption via modes of administration such as smoking or using a bong may increase the risk of negative health outcomes.

重新用于医疗用途的娱乐性药物。大麻
大麻作为一种药物有着悠久的历史,直到19世纪后期才成为医疗实践的一部分。20世纪中期,大麻二酚(CBD)和四氢大麻酚(THC)的发现,以及在接下来的几十年里,内源性大麻素系统(ECS)的各种成分的发现,再次将大麻作为一种潜在的治疗药物带回了公众的视野。目前,大麻正在世界各地的社区中用于娱乐和医疗目的。在医疗用途方面,可由医生开具处方,或为缓解症状等医疗目的合法或非法购买。大麻作为一种药物的证据仍然是一个新兴领域,虽然已经阐明了多种疾病的潜在作用机制,包括癌症、癫痫和慢性疼痛,但仍然缺乏高质量的人体随机对照试验。尽管人们普遍认为,大麻与所有其他药物一样,既有潜在的益处,也有潜在的危害,长期吸食大麻,即使是出于医疗原因,也可能没有风险。此外,通过吸烟或使用烟管等方式进行的消费可能会增加对健康产生负面影响的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CNS Spectrums
CNS Spectrums 医学-精神病学
CiteScore
6.20
自引率
6.10%
发文量
239
审稿时长
>12 weeks
期刊介绍: CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.
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